Gui Yibei, Zhao Jiale, Wu Wei, Li Xueqing, Wang Lijun, Wang Hailin, Luo Yiyang, Ding Xueliang, Li Xiaolan, Yuan Chengfu
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, 443002, China.
Third grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, 443002, China.
Curr Pharm Des. 2025 Jun 25. doi: 10.2174/0113816128373990250609210655.
Long noncoding RNAs (LncRNAs) represent a group of long noncoding RNA molecules exceeding 200 nt in length and lacking the capacity for protein coding. In recent years, the function and progress of lncRNA have attracted the attention of more and more researchers. Specifically, the long non-coding RNA, TSIX (TSIX transcript, XIST antisense RNA), plays a significant role in ensuring random X-chromosome inactivation. Recent investigations have highlighted the involvement of lncRNA TSIX in the development of various cancers, emphasizing its crucial functions in tumorigenesis. TSIX has emerged as a novel cancerassociated lncRNA and it is identified for its aberrant expression in diverse tumors, such as those of the breast, gastric, hepatocellular, head and neck, lung, esophageal squamous cell, and uterine smooth muscle. Furthermore, lncRNA TSIX regulates mRNA expression by binding to specific miRNAs, utilizing a competitive endogenous RNA regulatory mechanism. This interaction significantly influences tumor cell proliferation, migration, invasion, and apoptosis. LncRNA TSIX may serve as a useful biomarker or a prospective therapeutic target in a variety of malignant cancers because of the biological functions and mechanisms associated with it.
长链非编码RNA（LncRNAs）是一类长度超过200个核苷酸且缺乏蛋白质编码能力的长链非编码RNA分子。近年来，lncRNA的功能和研究进展吸引了越来越多研究者的关注。具体而言，长链非编码RNA TSIX（TSIX转录本，XIST反义RNA）在确保随机X染色体失活中发挥着重要作用。最近的研究强调了lncRNA TSIX参与多种癌症的发生发展，突显了其在肿瘤发生中的关键作用。TSIX已成为一种新型的癌症相关lncRNA，其在多种肿瘤中存在异常表达，如乳腺癌、胃癌、肝细胞癌、头颈癌、肺癌、食管鳞状细胞癌和子宫平滑肌肿瘤。此外，lncRNA TSIX通过与特定的微小RNA（miRNAs）结合，利用竞争性内源RNA调控机制来调节mRNA表达。这种相互作用显著影响肿瘤细胞的增殖、迁移、侵袭和凋亡。由于lncRNA TSIX相关的生物学功能和机制，它可能成为多种恶性肿瘤中有用的生物标志物或潜在的治疗靶点。
