Zhang Yuan, Liu Jing-Bo, Liu Meng-Jun, Liu Jing, Zhang Jing
Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China.
World J Psychiatry. 2025 Jun 19;15(6):105568. doi: 10.5498/wjp.v15.i6.105568.
Cervical cancer is a significant health concern among females in perimenopause, with a high prevalence of depression in this population. The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer. We hypothesized that socioeconomic status, disease characteristics, and quality of life factors contributed to the development of depression in these patients.
To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.
A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center. Patients were divided into a non-depression group ( = 152) and a depression group ( = 102) based on whether depression occurred after treatment. Data collection included demographic, clinical, and psychosocial factors. The Hamilton Depression Rating Scale was used to assess depression. Logistic regression analysis was performed to identify risk factors.
Patients with depression more often had low income (< 4000 China yuan: 66.7% 6.6%, < 0.001), initial disease onset (70.6% 57.2%, = 0.001), low social support (70.6% 55.3%, = 0.014), pathological stages III-IV (70.6% 41.5%, < 0.001), high pain level (65.7% 34.2%, < 0.001), and poor sleep quality (67.6% 32.2%, < 0.001). Logistic regression identified low income [odds ratio (OR) = 32.606, < 0.001], initial disease onset (OR = 4.282, = 0.001), pathological stages III-IV (OR = 4.123, = 0.0005), high pain level (OR = 1.181, = 0.0000434), and poor sleep quality (OR = 3.094, = 0.0041) as key risk factors.
Low income, initial onset, low support, advanced stages, high pain, and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer. Studies investigating interventions for this population are needed.
宫颈癌是围绝经期女性的一个重大健康问题，该人群中抑郁症的患病率很高。本研究的目的是探讨围绝经期宫颈癌患者抑郁症的相关危险因素。我们假设社会经济状况、疾病特征和生活质量因素会导致这些患者患抑郁症。
调查围绝经期宫颈癌患者抑郁症的相关危险因素。
对一家单一中心收治的254例围绝经期宫颈癌患者进行回顾性研究。根据治疗后是否发生抑郁症，将患者分为非抑郁症组（ = 152）和抑郁症组（ = 102）。数据收集包括人口统计学、临床和心理社会因素。采用汉密尔顿抑郁量表评估抑郁情况。进行逻辑回归分析以确定危险因素。
抑郁症患者更常出现低收入（<4000元人民币：66.7% 6.6%， < 0.001）、疾病初发（70.6% 57.2%， = 0.001）、社会支持低（70.6% 55.3%， = 0.014）、病理分期为III - IV期（70.6% 41.5%， < 0.001）、疼痛程度高（65.7% 34.2%， < 0.001）和睡眠质量差（67.6% 32.2%， < 0.001）。逻辑回归确定低收入[比值比（OR） = 32.606， < 0.001]、疾病初发（OR = 4.282， = 0.001）、病理分期III - IV期（OR = 4.123， = 0.0005）、疼痛程度高（OR = 1.181， = 0.0000434）和睡眠质量差（OR = 3.094， = 0.0041）为关键危险因素。
低收入、初发、支持低、晚期、疼痛程度高和睡眠质量差增加了围绝经期宫颈癌患者的抑郁风险。需要开展针对该人群的干预措施研究。
