Evaluation of the Protective Effects of Moringa oleifera, Zingiber officinale, and Allium sativum in a Rat Model of Chronic Kidney Disease (CKD).

BACKGROUND

Oxidative stress plays a key role in the development and progression of chronic kidney disease (CKD). In this study, it has been hypothesized that the extract of  leaves, rhizomes, and cloves together might exert a protective effect against adenine-induced CKD in rats.

METHODS

Rats were randomly divided into five groups: Group 1: normal control; Group 2: disease control; Group 3: CKD + polyherbal extract (250 mg/kg); Group 4: CKD + polyherbal extract (500 mg/kg); Group 5: CKD + polyherbal extract (1500 mg/kg). CKD was induced by feeding rats a 0.3% adenine-mixed diet for 28 days. Polyherbal extract was administered to rats, except for Groups 1 and 2, for 28 days.

RESULTS

Experimental animals receiving treatment with polyherbal extract showed significant improvement in water intake (p< 0.001), urine volume (p< 0.01), urine creatinine (p < 0.05), plasma creatinine (p < 0.01), and blood urea nitrogen(p<0.05). Furthermore, the combined extract showed a potential effect in reducing oxidative stress and fibrosis, indicated by reduced hypertrophy in kidney tissue.

CONCLUSION

Polyherbal extract containing leaves, rhizomes, and clove extracts showed a reduction in fibrosis and oxidative stress, and thus, this polyherbal extract combination could be explored in-depth for its therapeutic potential in CKD.