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辣木、生姜和大蒜对慢性肾脏病（CKD）大鼠模型保护作用的评估

Evaluation of the Protective Effects of Moringa oleifera, Zingiber officinale, and Allium sativum in a Rat Model of Chronic Kidney Disease (CKD).

作者信息

Jalgaonkar Manjiri P, Bale Rajeshwari K, Singh Alok D, Doshi Gaurav M, Raheja Radhika K, Kulkarni Yogesh A, Oza Manisha J

机构信息

Quality Assurance, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.

Pharmacology, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.

出版信息

Cureus. 2025 May 26;17(5):e84856. doi: 10.7759/cureus.84856. eCollection 2025 May.

DOI:10.7759/cureus.84856
PMID:40575233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12197805/
Abstract

BACKGROUND

Oxidative stress plays a key role in the development and progression of chronic kidney disease (CKD). In this study, it has been hypothesized that the extract of  leaves, rhizomes, and cloves together might exert a protective effect against adenine-induced CKD in rats.

METHODS

Rats were randomly divided into five groups: Group 1: normal control; Group 2: disease control; Group 3: CKD + polyherbal extract (250 mg/kg); Group 4: CKD + polyherbal extract (500 mg/kg); Group 5: CKD + polyherbal extract (1500 mg/kg). CKD was induced by feeding rats a 0.3% adenine-mixed diet for 28 days. Polyherbal extract was administered to rats, except for Groups 1 and 2, for 28 days.

RESULTS

Experimental animals receiving treatment with polyherbal extract showed significant improvement in water intake (p< 0.001), urine volume (p< 0.01), urine creatinine (p < 0.05), plasma creatinine (p < 0.01), and blood urea nitrogen(p<0.05). Furthermore, the combined extract showed a potential effect in reducing oxidative stress and fibrosis, indicated by reduced hypertrophy in kidney tissue.

CONCLUSION

Polyherbal extract containing leaves, rhizomes, and clove extracts showed a reduction in fibrosis and oxidative stress, and thus, this polyherbal extract combination could be explored in-depth for its therapeutic potential in CKD.

摘要

背景

氧化应激在慢性肾脏病（CKD）的发生和发展中起关键作用。在本研究中，有人提出叶、根茎和丁香的提取物共同作用可能对腺嘌呤诱导的大鼠慢性肾脏病具有保护作用。

方法

将大鼠随机分为五组：第1组：正常对照组；第2组：疾病对照组；第3组：慢性肾脏病+多草药提取物（250毫克/千克）；第4组：慢性肾脏病+多草药提取物（500毫克/千克）；第5组：慢性肾脏病+多草药提取物（1500毫克/千克）。通过给大鼠喂食含0.3%腺嘌呤的混合饲料28天诱导慢性肾脏病。除第1组和第2组外，给大鼠服用多草药提取物28天。

结果

接受多草药提取物治疗的实验动物在饮水量（p<0.001）、尿量（p<0.01）、尿肌酐（p<0.05）、血浆肌酐（p<0.01）和血尿素氮（p<0.05）方面有显著改善。此外，联合提取物在减轻氧化应激和纤维化方面显示出潜在作用，肾组织肥大减轻表明了这一点。

结论

含有叶、根茎和丁香提取物的多草药提取物显示出纤维化和氧化应激减轻，因此，这种多草药提取物组合在慢性肾脏病治疗潜力方面值得深入研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/c5c534e6065e/cureus-0017-00000084856-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/aa7345dcdf3e/cureus-0017-00000084856-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/899e69e95eca/cureus-0017-00000084856-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/becd8ce5c7c7/cureus-0017-00000084856-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/7ab671ee6c92/cureus-0017-00000084856-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/3071997cf8a6/cureus-0017-00000084856-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/ef5e4b24c57d/cureus-0017-00000084856-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/5a0fb8af2a39/cureus-0017-00000084856-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/c5c534e6065e/cureus-0017-00000084856-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/aa7345dcdf3e/cureus-0017-00000084856-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/899e69e95eca/cureus-0017-00000084856-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/becd8ce5c7c7/cureus-0017-00000084856-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/7ab671ee6c92/cureus-0017-00000084856-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/3071997cf8a6/cureus-0017-00000084856-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/ef5e4b24c57d/cureus-0017-00000084856-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/5a0fb8af2a39/cureus-0017-00000084856-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5161/12197805/c5c534e6065e/cureus-0017-00000084856-i08.jpg

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