Deterville Laurie, Lasserre Jérôme Frédéric, Toma Selena
Department of Periodontology, Institut de Médecine Dentaire et de Stomatologie, Cliniques Universitaires Saint Luc, Université catholique de Louvain, Brussels, Belgium.
Front Dent Med. 2025 Jun 12;6:1568889. doi: 10.3389/fdmed.2025.1568889. eCollection 2025.
Peri-implantitis, an inflammatory condition around dental implants, is challenging to manage with conventional non-surgical treatments alone. Emerging adjunctive therapies like glycine air-polishing and injectable platelet-rich fibrin (i-PRF) show potential to enhance decontamination.
To clinically and radiographically evaluate the efficacy of glycine air-polishing and the adjunctive use of injectable platelet rich fibrin (i-PRF) for the non-surgical treatment of slight peri-implantitis.
For this prospective case series, nine patients ( = 14 implants), with at least one implant with a slight peri-implantitis (radiographic bone loss visible and up to 4 mm) were enrolled. All treated implants received the same treatment: non-surgical mechanical debridement with an air abrasive device (PERIOFLOW®) followed by a subgingival irrigation with an injectable platelet rich fibrin (i-PRF). The following clinical parameters were measured: Plaque Index (PI), Bleeding on Probing (BoP), Suppuration on Probing (SoP), Probing Pocket Depth (PPD), Relative Attachment Level (RAL) and Recession (REC). They were assessed at baseline (M0), 3 and 6 months (M3 and M6). To compare bone level (BL), radiographs were taken at M0 and M6 ( > 0.05, ANOVA, Bonferroni).
Results indicated that PI significantly decreased over 6 months to a mean value of <0.05. Both BoP ( < 0.05) and SoP ( < 0.05) were substantially reduced at 3 months, although a slight increase was noted at 6 months. Mean PPD was 3.61 ± 0.25 mm ( < 0.05) at M6, and RAL gain was significantly improved at 6 months (7.76 ± 0.34 mm, < 0.05). BL showed a significant grain at 6 months ( < 0.05). Most mucosal recession occurred within the first 3 months, with no significant change at 6 months.
The application of i-PRF after a subgingival debridement using glycine air-polishing shows significant improvement of clinical parameters and a bone level stability for at least six months. However, if we consider that no bleeding on probing is needed to control the disease, none of the implants were considered successfully treated. Further randomized clinical trials are needed to evaluate the benefits of i-PRF as an adjuvant to the treatment of peri-implantitis.
种植体周围炎是一种发生在牙种植体周围的炎症性疾病，仅用传统的非手术治疗方法难以处理。新兴的辅助治疗方法，如甘氨酸空气抛光和可注射富血小板纤维蛋白（i-PRF），显示出增强去污效果的潜力。
通过临床和影像学评估甘氨酸空气抛光以及可注射富血小板纤维蛋白（i-PRF）辅助治疗轻度种植体周围炎的疗效。
在这个前瞻性病例系列研究中，纳入了9名患者（共14颗种植体），这些患者至少有一颗种植体存在轻度种植体周围炎（可见影像学骨吸收且骨吸收达4毫米）。所有接受治疗的种植体均接受相同治疗：先用空气研磨装置（PERIOFLOW®）进行非手术机械清创，然后用可注射富血小板纤维蛋白（i-PRF）进行龈下冲洗。测量以下临床参数：菌斑指数（PI）、探诊出血（BoP）、探诊有脓（SoP）、探诊深度（PPD）、相对附着水平（RAL）和牙龈退缩（REC）。在基线（M0）、3个月和6个月（M3和M6）时对这些参数进行评估。为比较骨水平（BL），在M0和M6时拍摄X光片（方差分析，Bonferroni检验，P>0.05）。
结果表明，PI在6个月内显著降低，平均值<0.05。BoP（P<0.05）和SoP（P<0.05）在3个月时均大幅降低，不过在6个月时略有上升。M6时平均PPD为3.61±0.25毫米（P<0.05），RAL在6个月时显著改善（7.76±0.34毫米，P<0.05）。BL在6个月时显示出显著改善（P<0.05）。大多数黏膜退缩发生在最初3个月内，6个月时无显著变化。
在使用甘氨酸空气抛光进行龈下清创后应用i-PRF，临床参数有显著改善，且骨水平至少在6个月内保持稳定。然而，如果认为控制疾病不需要探诊无出血，那么没有一颗种植体被视为成功治疗。需要进一步的随机临床试验来评估i-PRF作为种植体周围炎治疗辅助手段的益处。
