Hegde Shreya, Chogtu Bharti, Magazine Rahul, Prabhu Ravindra
Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Department of Respiratory Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Biochem Res Int. 2025 Jun 19;2025:5428052. doi: 10.1155/bri/5428052. eCollection 2025.
Diabetic kidney disease is a major cause of end-stage kidney disease. Various metabolic, hemodynamic, inflammatory, and profibrotic factors secondary to diabetes mellitus result in complex intracellular signaling, which in turn is responsible for the functional and structural changes associated with diabetic kidney disease. The beneficial effects of β-adrenergic agonists on renal cells bearing β-adrenergic receptors in diabetic kidney disease models have been reported. This narrative review explains the various mechanisms by which β-adrenergic agonists can have potential beneficial effects on diabetic kidney disease and highlights various in vitro, animal and human studies which lend credence to this hypothesis. It also touches upon the challenges and future concerns regarding their use in patients with this condition.
糖尿病肾病是终末期肾病的主要病因。糖尿病继发的各种代谢、血流动力学、炎症和促纤维化因素导致复杂的细胞内信号传导，进而导致与糖尿病肾病相关的功能和结构变化。已有报道称，β-肾上腺素能激动剂对糖尿病肾病模型中表达β-肾上腺素能受体的肾细胞具有有益作用。这篇叙述性综述解释了β-肾上腺素能激动剂对糖尿病肾病可能产生潜在有益作用的各种机制，并重点介绍了支持这一假说的各种体外、动物和人体研究。它还涉及在这种疾病患者中使用β-肾上腺素能激动剂的挑战和未来关注点。
