Behshood Parisa, Tajbakhsh Elahe
Department of Biology, Islamic Azad University, Shahrekord Unit, Shahrekord, Iran.
Caspian J Intern Med. 2025 Mar 11;16(2):225-232. doi: 10.22088/cjim.16.2.225. eCollection 2025.
Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association between antibiotic resistance and biofilm formation in methicillin-resistant (MRSE) isolates.
A comprehensive search was conducted through data medical data bases using a combination of mesh terms. The data were analyzed using STATA meta-analysis software, and a random effects model was employed to determine the pooled prevalence with a 95% confidence interval (CI).
Our findings revealed that the prevalence of MRSA was 61.75% (95% CI: 35.6-99.1). The cumulative rate of biofilm formation in MRSE strains was reported to be 83.4% (95% CI: 47.8-99.4). Among the biofilm-related genes, the gene exhibited the highest frequency (98%), followed by the gene with a frequency of 84%.
Out of the seven, three documented a positive association. Given the propensity of MRSE strains to form biofilms, it is crucial to implement preventive measures against infections caused by these strains.
生物膜是微生物的有组织群落，包裹在自身产生的基质中，附着于表面，在各种环境中可能产生有益和有害影响。这些生物膜与人类严重感染有关。我们研究了耐甲氧西林金黄色葡萄球菌（MRSE）分离株中抗生素耐药性与生物膜形成之间的关联。
通过使用网状术语组合在医学数据库中进行全面检索。使用STATA荟萃分析软件对数据进行分析，并采用随机效应模型确定合并患病率及95%置信区间（CI）。
我们的研究结果显示，MRSA的患病率为61.75%（95%CI：35.6 - 99.1）。据报道，MRSE菌株中生物膜形成的累积率为83.4%（95%CI：47.8 - 99.4）。在与生物膜相关的基因中，某基因出现频率最高（98%），其次是另一基因，频率为84%。
在七项研究中，三项记录了正相关关系。鉴于MRSE菌株形成生物膜的倾向，对这些菌株引起的感染实施预防措施至关重要。
