Demetz Matthias, Krigers Aleksandrs, Klingenschmid Julia, Thomé Claudius, Freyschlag Christian F, Kerschbaumer Johannes
Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria.
Acta Neurochir (Wien). 2025 Jun 27;167(1):178. doi: 10.1007/s00701-025-06594-5.
Socioeconomic factors influence survival in different cancer types. This study aimed to assess the impact of various socioeconomic factors, including education, marital status, lifestyle, and social network, on survival in patients with Isocitrate dehydrogenase (IDH) wildtype gliomas.
We conducted a retrospective analysis of 309 adult patients with de novo diagnosed IDH wildtype gliomas who underwent surgical treatment at our institution between 2014 and 2022. Socioeconomic factors, including education, marital status, employment, language, lifestyle (alcohol abuse, smoking, BMI), and social network were assessed. Progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox regression models.
Education, alcohol abuse, and age significantly influenced OS. Patients with higher education had significantly lower tumor volumes (p = 0.037) and longer survival (p = 0.001). Alcohol abuse was associated with significantly shorter OS (8.6 vs. 17.9 months, p = 0.034). Patients aged over 65 years showed significantly shorter OS in this study (14.9 months vs 33.2 months, p < 0.001). Native and non-native German speakers had similar outcomes. Marital status did not significantly affect survival.
Socioeconomic and lifestyle factors, especially higher education and alcohol abuse, significantly impact survival in IDH wildtype glioma patients. These findings suggest that, in addition to molecular features and oncological treatment, socioeconomic and lifestyle factors also play a crucial role in influencing the prognosis of patients with IDH wildtype gliomas.
社会经济因素影响不同癌症类型的生存率。本研究旨在评估包括教育程度、婚姻状况、生活方式和社会网络等各种社会经济因素对异柠檬酸脱氢酶（IDH）野生型胶质瘤患者生存率的影响。
我们对2014年至2022年间在本机构接受手术治疗的309例初诊IDH野生型胶质瘤成年患者进行了回顾性分析。评估了社会经济因素，包括教育程度、婚姻状况、就业情况、语言、生活方式（酗酒、吸烟、体重指数）和社会网络。使用Kaplan-Meier和Cox回归模型分析无进展生存期（PFS）和总生存期（OS）。
教育程度、酗酒和年龄对总生存期有显著影响。教育程度较高的患者肿瘤体积显著较小（p = 0.037），生存期较长（p = 0.001）。酗酒与显著较短的总生存期相关（8.6个月对17.9个月，p = 0.034）。在本研究中，65岁以上的患者总生存期显著较短（14.9个月对33.个月，p < = 0.001）。以德语为母语和非母语的患者有相似的结果。婚姻状况对生存率没有显著影响。
社会经济和生活方式因素，尤其是较高的教育程度和酗酒，对IDH野生型胶质瘤患者的生存率有显著影响。这些发现表明，除了分子特征和肿瘤治疗外，社会经济和生活方式因素在影响IDH野生型胶质瘤患者的预后方面也起着关键作用。
