一例经肾活检偶然发现的血清阴性狼疮性肾炎病例。
A Case of Seronegative Lupus Nephritis Detected Incidentally by Renal Biopsy.
作者信息
Mima Akira, Matsuki Takamasa, Nakamoto Takahiro, Saito Yuta, Morikawa Takaaki, Kure Sakura, Matsumoto Keishi, Lee Shinji
机构信息
Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka, Japan
Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka, Japan.
出版信息
In Vivo. 2025 Jul-Aug;39(4):2328-2332. doi: 10.21873/invivo.14029.
BACKGROUND/AIM: Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are autoimmune diseases that affect multiple organ systems with the production of pathological autoantibodies.
CASE REPORT
We describe the case of a 19-year-old man who had microscopic hematuria and mild proteinuria. No skin rash, joint symptoms, serositis, neuropathy, or cytopenia were observed. Renal biopsy revealed the thickness of the glomerular basement membrane, granular deposits of C1q along mesangial areas, and high electron density deposits in basement membrane on the epithelial side of the glomerulus. After operating renal biopsy, laboratory tests were performed and the results were not associated with SLE. This leads to the diagnosis of class V seronegative LN. The patient achieved remission only with angiotensin II receptor blocker without immunosuppressive drugs. There have been few reports of seronegative LN.
CONCLUSION
Our case report presents a case of seronegative LN identified incidentally during renal biopsy.
背景/目的：系统性红斑狼疮（SLE）和狼疮性肾炎（LN）是自身免疫性疾病，可通过产生病理性自身抗体影响多个器官系统。
病例报告
我们描述了一名19岁男性的病例，该患者有镜下血尿和轻度蛋白尿。未观察到皮疹、关节症状、浆膜炎、神经病变或血细胞减少。肾活检显示肾小球基底膜增厚，系膜区有C1q颗粒状沉积，肾小球上皮侧基底膜有高电子密度沉积物。肾活检术后进行了实验室检查，结果与SLE无关。这导致诊断为Ⅴ型血清阴性LN。该患者仅使用血管紧张素II受体阻滞剂而未使用免疫抑制药物就实现了缓解。血清阴性LN的报道很少。
结论
我们的病例报告展示了一例在肾活检过程中偶然发现的血清阴性LN病例。
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