Okuyan Betul, Ay Pınar, Sancar Mesut, Ozcan Vildan, Durak-Albayrak Ozge, Turker Meltem, Uney Arman, Voils Corrine I
Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
Department of Public Health, School of Medicine, Marmara University, Istanbul, Türkiye.
Int J Clin Pharm. 2025 Jun 28. doi: 10.1007/s11096-025-01959-3.
Adherence to newly prescribed cardiometabolic medications is low. It is crucial to develop personalized behavioural interventions to address patients' specific medication adherence barriers.
The aim of this study was to develop a behavioural theory-based New Medicine Service (NMS) toolkit for use by community pharmacists in Türkiye to identify and address reasons for nonadherence in patients newly started on medications for hypertension, diabetes, or dyslipidemia.
This multistage study used a literature search, expert panel, cognitive interviews, and survey with patients to identify reasons for nonadherence to include in the Turkish DOSE Nonadherence Scale. A short form of the toolkit was generated by asking the patients to select the most challenging reasons for nonadherence. To identify relevant pharmacist interventions, the theoretical domains framework (TDF-14) (v2) domains related to reasons for nonadherence were identified and matched with behavioural change techniques (BCTs). To assess the applicability of the proposed pharmacist interventions in daily practice, an online survey of community pharmacists was conducted using a modified Delphi study.
The final list of reasons for nonadherence consisted of 31 items, of which 14 identified as most challenging by patients were selected for inclusion in the short form of the NMS toolkit. For the full 31 reasons, ten domains of TDF-14 and 18 BCTs were selected. In the Delphi study (response rate: 83.3%), 68 of the 81 (84.0%) pharmacist interventions were found to be applicable, corresponding to 15 BCTs.
The behavioural theory-based NMS toolkit was developed for use by community pharmacists to identify and address reasons for nonadherence in patients newly started on medications to manage hypertension, diabetes, or dyslipidemia. This toolkit will assist community pharmacists in developing personalized interventions to overcome nonadherence problems in patients who are newly starting medications. Future studies should be conducted to assess the impact of this new toolkit on patients' medication adherence levels and clinical outcomes.
新开具的心脏代谢药物的依从性较低。制定个性化行为干预措施以解决患者特定的药物依从性障碍至关重要。
本研究的目的是开发一种基于行为理论的新药物服务(NMS)工具包,供土耳其的社区药剂师使用,以识别和解决新开始服用高血压、糖尿病或血脂异常药物的患者不依从的原因。
这项多阶段研究采用文献检索、专家小组、认知访谈以及对患者的调查,以确定纳入土耳其剂量不依从量表的不依从原因。通过让患者选择最具挑战性的不依从原因,生成了该工具包的简短形式。为了确定相关的药剂师干预措施,确定了与不依从原因相关的理论领域框架(TDF-14)(第2版)领域,并将其与行为改变技术(BCTs)相匹配。为了评估所提议的药剂师干预措施在日常实践中的适用性,使用改良的德尔菲研究对社区药剂师进行了在线调查。
不依从原因的最终列表包含31项,其中患者认为最具挑战性的14项被选入NMS工具包的简短形式。对于全部31个原因,选择了TDF-14的10个领域和18个BCTs。在德尔菲研究(回复率:83.3%)中,81项药剂师干预措施中的68项(84.0%)被认为是适用的,对应15个BCTs。
开发了基于行为理论的NMS工具包,供社区药剂师使用,以识别和解决新开始服用治疗高血压、糖尿病或血脂异常药物的患者不依从的原因。该工具包将帮助社区药剂师制定个性化干预措施,以克服新开始用药患者的不依从问题。未来应开展研究,以评估这一新工具包对患者药物依从性水平和临床结局的影响。