Hajhashemy Zahra, Ziaei Rahele, Bagherniya Mohammad, Sahebkar Amirhossein
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 28. doi: 10.1007/s00210-025-04314-5.
The influence of resveratrol on renal function was previously examined; nevertheless, the findings are inconsistent. Therefore, this systematic review and dose-response meta-analysis was performed to evaluate the effect of resveratrol on renal function. A comprehensive search was performed in Web of Science, PubMed, Scopus, and Google Scholar up to March 1, 2025. Randomized controlled trials (RCTs) that investigated the effect of resveratrol supplementation on the urea, uric acid, blood urea nitrogen (BUN), albumin, total protein, glomerular filtration rate (GFR), and creatinine (Cr) were included. A total of 2299 participants from 31 studies were included. Meta-analysis of studies indicated that resveratrol supplementation in comparison to placebo had favorable effects on the values of BUN [weighted mean difference (WMD) = - 1.20; 95% CI: - 1.89, - 0.51 mg/dL; I = 84.6%; 95% CI: 77, 90%; Tau = 1.41; P < 0.001]. Based on the subgroup analysis, significant improvement was seen in Cr and GFR in the subgroup of participants without diabetes. Additionally, resveratrol supplementation for more than 8 weeks or at doses higher than 500 mg/d significantly elevated GFR and total protein values, respectively. However, the circulating values of albumin and uric acid were not affected by resveratrol supplementation. Although dose-response analysis was conducted for dosage and duration of intervention, no significant results were found. Resveratrol supplementation might improve GFR, BUN, creatinine, and total protein concentrations in adults. However, it did not significantly affect the circulating values of albumin and uric acid.
此前已对白藜芦醇对肾功能的影响进行了研究；然而，研究结果并不一致。因此，进行了这项系统评价和剂量反应荟萃分析，以评估白藜芦醇对肾功能的影响。截至2025年3月1日，在Web of Science、PubMed、Scopus和谷歌学术上进行了全面检索。纳入了调查补充白藜芦醇对尿素、尿酸、血尿素氮（BUN）、白蛋白、总蛋白、肾小球滤过率（GFR）和肌酐（Cr）影响的随机对照试验（RCT）。共纳入了来自31项研究的2299名参与者。研究的荟萃分析表明，与安慰剂相比，补充白藜芦醇对BUN值有有利影响[加权平均差（WMD）=-1.20；95%置信区间：-1.89，-0.51mg/dL；I=84.6%；95%置信区间：77，90%；Tau=1.41；P<0.001]。基于亚组分析，在无糖尿病参与者亚组中，Cr和GFR有显著改善。此外，补充白藜芦醇超过8周或剂量高于500mg/d时，分别显著提高了GFR和总蛋白值。然而，补充白藜芦醇未影响白蛋白和尿酸的循环值。尽管对干预的剂量和持续时间进行了剂量反应分析，但未发现显著结果。补充白藜芦醇可能会改善成年人的GFR、BUN、肌酐和总蛋白浓度。然而，它并未显著影响白蛋白和尿酸的循环值。
