Anti-implantation activity of the fruit of Lagenaria breviflora Robert.

The fruit of Lagenaria breviflora Robert (Adenopus breviflorus Benth) family Cucurbitaceae used by natives as an abortifacient in Nigeria, was investigated for anti-implantation activity. The ethyl acetate extract of the whole fruit and methanol extract of the seed were very toxic to rats. Using ten female virgin albino rats for each extract, the World Health Organization special protocol and doses on a moisture-free basis: 20 g/kg whole fruit methanol extract gave 60% anti-implantation activity, 2.5 g/kg fruit pulp gave 80% and 5 g/kg fruit pulp gave 100% activity while 2 g/kg seed also gave 100% activity but four of the rats died. Statistical evaluation of the data showed that the results were significant.