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按需平台提高了莫里斯水迷宫实验的准确性。

On-demand platform improves accuracy of the Morris water maze procedure.

作者信息

Buresová O, Krekule I, Zahálka A, Bures J

出版信息

J Neurosci Methods. 1985 Oct;15(1):63-72. doi: 10.1016/0165-0270(85)90062-7.

DOI:10.1016/0165-0270(85)90062-7
PMID:4058062
Abstract

In order to prevent chance finding of the hidden target in the Morris water tank task, the rigid underwater platform is replaced with a collapsible platform, resting at the bottom of the pool. A computerized videosystem tracks the rat's movement across the pool and raises the platform when the animal has stayed in the target area for a predetermined time. Acquisition of the task with the collapsible platform proceeds at a similar rate as with the rigid platform when the criterion conditions are easy (target distance 15 cm, target time 2.5 s), but gradually deteriorates when the target time increases to 10.0 s. Successful solution of the modified task requires accurate localization of the target under open loop conditions and is thus well suited for investigation of the fine structure of the cognitive maps and of their changes induced by lesions or drugs.

摘要

为防止在莫里斯水迷宫任务中偶然发现隐藏目标,将刚性水下平台替换为可折叠平台,该平台位于水池底部。计算机化视频系统跟踪大鼠在水池中的移动,并在动物在目标区域停留预定时间后升起平台。当标准条件容易时(目标距离15厘米,目标时间2.5秒),使用可折叠平台进行任务习得的速度与使用刚性平台时相似,但当目标时间增加到10.0秒时,习得速度会逐渐下降。成功解决修改后的任务需要在开环条件下准确地定位目标,因此非常适合研究认知地图的精细结构以及由损伤或药物引起的认知地图变化。

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