Rothmund M, Pitsch W
Langenbecks Arch Chir. 1985;366:113-9. doi: 10.1007/BF01836613.
Simple suture as standard treatment of perforated ulcer has been doubted because of high postoperative morbidity and reoperation-rate due to recurrent disease. Prospective studies showed that definitive surgery can decrease morbidity without increasing mortality. Selection is the important point. Patients with risk factors and perforation of acute ulcer should be treated by simple suture, patients without risk factors and perforation of chronic ulcer by definitive surgery (SPV + suture).
由于术后发病率高以及因疾病复发导致的再次手术率高,单纯缝合作为穿孔性溃疡的标准治疗方法一直受到质疑。前瞻性研究表明,确定性手术可降低发病率而不增加死亡率。关键在于选择。有危险因素且急性溃疡穿孔的患者应采用单纯缝合治疗,无危险因素且慢性溃疡穿孔的患者应采用确定性手术(胃大部切除术+缝合)治疗。