McKay A J, McArdle C S
Br J Surg. 1982 Jun;69(6):319-20. doi: 10.1002/bjs.1800690609.
Cimetidine is thought to have accelerated the reduction in elective peptic ulcer surgery but its effect on the incidence of perforated peptic ulcer has not been reported. A 15-year (1966-1980) review of peptic ulcer surgery in a district general hospital is presented. Since cimetidine became available (November 1976), the mean annual number of elective operations has fallen from 91.4 to 50.5 (45 per cent reduction). The number of perforations has fallen from 40.6 to 36.5 (10 per cent reduction). One hundred and five patients treated for perforation (97 duodenal, 8 gastric) from 1978 to 1980 were reviewed in detail. Of the 64 patients with a chronic ulcer, 8 were taking cimetidine when their ulcers perforated and a further 8 had been on the drug previously. Cimetidine has substantially reduced elective peptic ulcer surgery. There appears to have been no equivalent reduction in the incidence of perforation.
西咪替丁被认为加速了择期性消化性溃疡手术数量的减少，但其对消化性溃疡穿孔发生率的影响尚无报道。本文呈现了一家区综合医院15年（1966 - 1980年）的消化性溃疡手术回顾。自西咪替丁上市（1976年11月）以来，择期手术的年平均数量从91.4例降至50.5例（减少了45%）。穿孔病例数从40.6例降至36.5例（减少了10%）。对1978年至1980年期间接受穿孔治疗的105例患者（97例十二指肠溃疡，8例胃溃疡）进行了详细回顾。在64例患有慢性溃疡的患者中，8例溃疡穿孔时正在服用西咪替丁，另有8例此前一直在服用该药。西咪替丁显著减少了择期性消化性溃疡手术。穿孔发生率似乎没有相应降低。
