Wahl R A, Goretzki P E, Joseph K, Röher H D
Langenbecks Arch Chir. 1985;366:61-8. doi: 10.1007/BF01836607.
Different concepts are required by different tumors: anaplastic carcinomas rarely are accessible to curative surgery, but tumor reduction gives sense in combined concepts. In follicular carcinomas general ("near"-) total thyroidectomy + radioiodine + hormonal suppressive therapy is recommended, with respect to the high incidence of distant metastases even in low 1 degree Tu-stages. Papillary carcinomas allow a stage related procedure with exceptions from total thyroidectomy: no reintervention for "occult" carcinomas and-in patients under 40 years of age-hemithyroidectomy for intrathyroid tumors without regional metastases. In C-Cell-carcinomas total thyroidectomy has to be accompanied by lymph-node dissections of various extent, depending on familiary or sporadic type and tumor-stage.
间变性癌很少能通过根治性手术治愈,但在综合治疗理念中,肿瘤缩小是有意义的。对于滤泡状癌,鉴于即使在低1期肿瘤阶段远处转移的发生率也很高,推荐行全甲状腺切除(“近”全甲状腺切除)+放射性碘+激素抑制治疗。乳头状癌可根据分期进行相应手术,但全甲状腺切除有例外情况:“隐匿性”癌无需再次干预,40岁以下甲状腺内无区域转移肿瘤的患者可行甲状腺半叶切除术。对于C细胞癌,全甲状腺切除必须根据家族性或散发性类型及肿瘤分期进行不同范围的淋巴结清扫。