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肥胖与非肥胖患者机器人肝切除术的比较:围手术期结局的多中心倾向评分匹配分析

Comparison of robotic liver resection in obese vs. non-obese patients: a multicentric propensity score-matched analysis of perioperative outcomes.

作者信息

Delvecchio Antonella, Caringi Silvio, Tedeschi Michele, Ratti Francesca, Magistri Paolo, Belli Andrea, Ceccarelli Graziano, Izzo Francesco, Spampinato Marcello Giuseppe, de'Angelis Nicola, Pessaux Patrick, Piardi Tullio, Di Benedetto Fabrizio, Aldrighetti Luca, Memeo Riccardo

机构信息

Unit of Hepato-Biliary and Pancreatic Surgery, "F. Miulli" General Hospital, Acquaviva delle Fonti, 70021, Bari, Italy.

Department of Surgery, Università Degli Studi Roma "Tor Vergata", 00133, Rome, Italy.

出版信息

Updates Surg. 2025 Jun 29. doi: 10.1007/s13304-025-02303-0.

Abstract

Obesity poses unique challenges in liver surgery, potentially affecting perioperative outcomes. While laparoscopic liver resection (LLR) has demonstrated clear benefits over open surgery, evidence regarding the impact of body mass index (BMI) on robotic liver resection (RLR) outcomes remains limited. This study aims to evaluate the influence of BMI on perioperative outcomes following RLR. A retrospective, multicenter analysis was conducted on patients undergoing RLR. A 3:1 propensity score matching (PSM) was performed to minimize confounding factors, creating two well-balanced groups: patients with BMI <30 and BMI ≥30. Perioperative outcomes, including operative time, blood loss, conversion rates, postoperative complications and R0 resection were compared between the two groups. After PSM, 472 patients were included (BMI <30: n = 354; BMI ≥30: n = 118). No significant differences were observed in operative time (244 ± 107 min vs. 256±120 min, p=0.271), blood loss (225 ± 254 mL vs. 201 ± 186 mL, p = 0.273), or conversion rates (4.5 vs. 3.4%, p=0.601). Overall postoperative complications were comparable between the two groups (14.4% vs.19.5%, p=0.203). ICU stay and hospital length of stay were similar between groups. R0 resection rate was comparable between the groups (95.4 vs. 95.4%, p = 1.000). The 90-day mortality rate was low in both groups (0.3 vs. 0%, p = 0.987). Our findings suggest that RLR is a safe and effective approach for patients regardless of BMI. Despite concerns regarding surgical complexity in obese patients, the robotic approach provides comparable perioperative outcomes in both obese and non-obese patients.

摘要

肥胖给肝脏手术带来了独特的挑战,可能会影响围手术期的结果。虽然腹腔镜肝切除术(LLR)已显示出比开放手术更明显的优势,但关于体重指数(BMI)对机器人肝切除术(RLR)结果影响的证据仍然有限。本研究旨在评估BMI对RLR术后围手术期结果的影响。对接受RLR的患者进行了一项回顾性多中心分析。进行了3:1的倾向评分匹配(PSM)以尽量减少混杂因素,创建了两个平衡良好的组:BMI<30的患者和BMI≥30的患者。比较了两组的围手术期结果,包括手术时间、失血量、转化率、术后并发症和R0切除率。PSM后,纳入了472例患者(BMI<30:n = 354;BMI≥30:n = 118)。在手术时间(244±107分钟 vs. 256±120分钟,p = 0.271)、失血量(225±254毫升 vs. 201±186毫升,p = 0.273)或转化率(4.5% vs. 3.4%,p = 0.601)方面未观察到显著差异。两组的总体术后并发症相当(14.4% vs. 19.5%,p = 0.203)。两组间ICU住院时间和住院时间相似。两组间R0切除率相当(95.4% vs. 95.4%,p = 1.000)。两组的90天死亡率均较低(0.3% vs. 0%,p = 0.987)。我们的研究结果表明,无论BMI如何,RLR对患者来说都是一种安全有效的方法。尽管人们担心肥胖患者的手术复杂性,但机器人手术方法在肥胖和非肥胖患者中都能提供相当的围手术期结果。

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