Mulaisho C, Utiger R D
Acta Endocrinol (Copenh). 1977 Jun;85(2):314-24. doi: 10.1530/acta.0.0850314.
Serum thyroxine-binding globulin (TBG) concentrations were measured by competitive ligand-binding assay in normal subjects and patients with a variety of abnormalities of thyroid hormone production or TBG production. The mean serum TBG concentration in 73 normal adults was 3.4 +/- 0.6 mg/100 ml. No correlations with age, sex or serum thyroxine (T4) or triiodothyronine (T3) concentrations were found. Serum TBG concentrations were normal in patients with hyperthyroidism. They were significantly elevated in hypothyroid patients, and fell to normal with thyroxine treatment. In pregnant women, serum TBG concentrations were markedly increased, being 7.1 +/- 1.2 (mean +/- SD) mg/100 ml in women in their first trimester, 9.0 +/- 1.0 mg/100 ml in the second trimester and 8.9 +/- 1.6 mg/100 ml in the third trimester. There was a positive correlation between serum TBG concentration and both serum T4 and serum T3 concentrations in pregnant women. Competitive ligand-binding assay is a simple and reliable method for TBG asay and yields results similar to those of electrophoretic saturation techniques.
采用竞争性配体结合分析法，对正常受试者以及患有各种甲状腺激素生成异常或甲状腺素结合球蛋白（TBG）生成异常的患者，测定其血清甲状腺素结合球蛋白（TBG）浓度。73名正常成年人的血清TBG平均浓度为3.4±0.6mg/100ml。未发现与年龄、性别、血清甲状腺素（T4）或三碘甲状腺原氨酸（T3）浓度存在相关性。甲状腺功能亢进患者的血清TBG浓度正常。甲状腺功能减退患者的血清TBG浓度显著升高，经甲状腺素治疗后降至正常。孕妇的血清TBG浓度明显升高，孕早期女性为7.1±1.2（均值±标准差）mg/100ml，孕中期为9.0±1.0mg/100ml，孕晚期为8.9±1.6mg/100ml。孕妇血清TBG浓度与血清T4和血清T3浓度均呈正相关。竞争性配体结合分析法是一种简单可靠的TBG检测方法，其结果与电泳饱和技术相似。
