Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Mol Biol Rep. 2022 Oct;49(10):9825-9840. doi: 10.1007/s11033-022-07502-1. Epub 2022 May 10.
More effective prognostic and diagnostic tools are urgently required for early detecting and treating triple-negative breast cancer, which is the most acute type of breast cancer because of its lower survival rate, aggressiveness, and non-response to various common treatments. So, it remains the most harmful malignancy for women worldwide. Recently, circular RNAs, as a group of non-coding RNAs, with covalently closed loop and high stability have been discovered, which can modulate gene expression through competing with endogenous microRNA sponges. This finding provided further insight into novel approaches for controlling genes affected in many disorders and malignancies. This review concentrates on the dysregulated expression of circRNAs like their diagnostic and prognostic values in TNBC. This review aims to focus on the abnormal expression of circRNAs and their diagnostic and prognostic values in TNBC. We used PubMed, Embase, and Web of Science databases and ClinicalTrials.gov to systematically search for all relevant clinical studies. This review is based on articles published in databases up to April 2022 with the following keywords: "Circular RNA", "CircRNA", "Triple-Negative Breast Cancer" and "TNBC". We conducted a review of published CircRNA profiled-research articles to identify candidate CircRNA biomarkers for TNBC. The review is registered on JBI at https://jbi.global/systematic-review-register . Accumulating evidence has shown that several circRNAs are downregulated and some are upregulated in TNBC. The results of these studies confirm that circRNAs might be potential biomarkers with the diagnostic, prognostic, and therapeutic target value for TNBC. We also consider the connection between circRNAs and TNBC cell proliferation, apoptosis, metastasis, and chemotherapy resistance and sensitivity.
迫切需要更有效的预后和诊断工具来早期检测和治疗三阴性乳腺癌，这种乳腺癌是最严重的乳腺癌类型，因为其存活率较低、侵袭性较强，并且对各种常见治疗方法没有反应。因此，它仍然是全世界女性最具危害性的恶性肿瘤。最近，环状 RNA 作为一类非编码 RNA，由于其共价闭环和高稳定性，已被发现可以通过与内源性 microRNA 海绵竞争来调节基因表达。这一发现为控制受多种疾病和恶性肿瘤影响的基因提供了新的方法。这篇综述集中讨论了 circRNAs 的失调表达及其在三阴性乳腺癌中的诊断和预后价值。这篇综述旨在重点关注 circRNAs 的异常表达及其在三阴性乳腺癌中的诊断和预后价值。我们使用了 PubMed、Embase 和 Web of Science 数据库以及 ClinicalTrials.gov 系统地搜索了所有相关的临床研究。这篇综述基于截至 2022 年 4 月在数据库中发表的文章，使用了以下关键词："Circular RNA"、"CircRNA"、"Triple-Negative Breast Cancer" 和 "TNBC"。我们对已发表的 circRNA 分析研究文章进行了综述，以确定三阴性乳腺癌的候选 circRNA 生物标志物。该综述已在 JBI 上注册，网址为 https://jbi.global/systematic-review-register。越来越多的证据表明，在三阴性乳腺癌中，一些 circRNAs 下调，而一些 circRNAs 上调。这些研究的结果证实，circRNAs 可能是具有诊断、预后和治疗靶值的潜在生物标志物。我们还考虑了 circRNAs 与三阴性乳腺癌细胞增殖、凋亡、转移和化疗耐药性和敏感性之间的关系。
