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播散性感染导致的骨关节炎侵袭的影响

The impact of osteoarticular invasion by Sp disseminated infection.

作者信息

Nora Arvilla Salas, Itzel Ovalle Mireles, Reynaldo Falcón Escobedo, Víctor Dimas Pecina, Marcos Rodriguez Ávalos, Diana Perales Martínez

机构信息

Department of Internal Medicine, ISSSTE General Hospital, San Luis Potosi, Mexico.

Pathology Servicie, Specialty Medical Hospital of La Salud, San Luis Potosi, Mexico.

出版信息

Med Mycol Case Rep. 2025 Jun 7;49:100710. doi: 10.1016/j.mmcr.2025.100710. eCollection 2025 Sep.

DOI:10.1016/j.mmcr.2025.100710
PMID:40584595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12205825/
Abstract

Coccidioidomycosis is a fungal infection caused by and . It leads to significant morbidity and mortality in both immunocompetent and immunocompromised individuals and is more prevalent in endemic regions. Fungal bone infections are rare, and osteoarticular involvement typically occurs secondary to hematogenous dissemination or direct cutaneous inoculation with contiguous spread. This case demonstrates osteoarticular involvement and the spread to adjacent structures, causing pain, restricting mobility, and deteriorating the patient's quality of life.

摘要

球孢子菌病是一种由[具体真菌名称缺失]引起的真菌感染。它在免疫功能正常和免疫功能低下的个体中都会导致显著的发病率和死亡率，并且在流行地区更为普遍。真菌性骨感染较为罕见，骨关节受累通常继发于血行播散或直接皮肤接种并伴有连续扩散。本病例展示了骨关节受累及向相邻结构的扩散，导致疼痛、活动受限，并使患者生活质量下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/76e127e386a7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/84aabec9a120/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/13fcc3450954/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/1dc5d76298cc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/05cacebdec5d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/8f9cd334f855/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/95627d2ec6e4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/cc1a10298011/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/819f712c57d3/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/76e127e386a7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/84aabec9a120/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/13fcc3450954/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/1dc5d76298cc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/05cacebdec5d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/8f9cd334f855/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/95627d2ec6e4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/cc1a10298011/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/819f712c57d3/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3a7/12205825/76e127e386a7/gr9.jpg

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本文引用的文献

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Coccidioidomycosis in Immunocompromised at a Non-Endemic Referral Center in Mexico.墨西哥一家非流行地区转诊中心免疫功能低下患者的球孢子菌病
J Fungi (Basel). 2024 Jun 18;10(6):429. doi: 10.3390/jof10060429.
2
Clinical Cases of Coccidioidomycosis in the Americas in the Period 1950-2021: Epidemiology Data, Diagnosis, and Treatment.1950 - 2021年美洲球孢子菌病临床病例：流行病学数据、诊断与治疗
Life (Basel). 2023 Oct 24;13(11):2109. doi: 10.3390/life13112109.
3
Coccidioidomycosis Osteoarticular Dissemination.球孢子菌病骨关节播散
J Fungi (Basel). 2023 Oct 11;9(10):1002. doi: 10.3390/jof9101002.
4
Fatal septic shock due to disseminated coccidioidomycosis: a case series and review of the literature.播散性球孢子菌病导致的致死性感染性休克：病例系列及文献复习。
BMC Infect Dis. 2023 Jun 26;23(1):430. doi: 10.1186/s12879-023-08379-6.
5
Disseminated coccidioidomycosis in immunocompetent patients in non-endemic areas: a case series and literature review.非流行地区免疫功能正常患者的播散性球孢子菌病：病例系列及文献综述
Eur J Clin Microbiol Infect Dis. 2022 Jun;41(6):925-939. doi: 10.1007/s10096-022-04447-y. Epub 2022 May 12.
6
Disseminated Coccidioidomycosis: Cutaneous, Soft Tissue, Osseous, and "Shotgun Intraparenchymal" Brain Disease.播散性球孢子菌病：皮肤、软组织、骨和“霰弹枪脑内”疾病。
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221075906. doi: 10.1177/23247096221075906.
7
A randomized, double-blind, placebo-controlled clinical trial of fluconazole as early empiric treatment of coccidioidomycosis pneumonia (Valley Fever) in adults presenting with community-acquired pneumonia in endemic areas (FLEET-Valley Fever).一项关于氟康唑作为球孢子菌病肺炎（山谷热）早期经验性治疗的随机、双盲、安慰剂对照临床试验，该试验针对流行地区出现社区获得性肺炎的成人（FLEET-山谷热）。
Contemp Clin Trials Commun. 2021 Oct 14;24:100851. doi: 10.1016/j.conctc.2021.100851. eCollection 2021 Dec.
8
A Case of Disseminated Coccidioidomycosis: When the Treasure Chest Wall Opened.播散性粗球孢子菌病 1 例：宝箱壁打开之时。
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211040629. doi: 10.1177/23247096211040629.
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J Investig Med. 2021 Feb;69(2):316-323. doi: 10.1136/jim-2020-001655.