Oliveira Neyara Dos Santos, Guimarães Reis Tercio, Souza Freitas Milena, Macêdo Marluce Matos, Zambrano Contreras Jean Carlos, Oliveira Márcio Campos, Bessa Júnior José
Postgraduate Program in Public Health, State University of Feira de Santana (UEFS), Feira de Santana, Bahia, Brazil.
Santa Casa de Misericórdia de Feira de Santana, Feira de Santana, Bahia, Brazil.
PeerJ. 2025 Jun 26;13:e19496. doi: 10.7717/peerj.19496. eCollection 2025.
Head and neck cancer (HNC) patients are known to have high nutritional risk and a high prevalence of malnutrition. The diagnosis of HNC, together with sequelae and other consequences of cancer treatment, directly impacts survival.
To determine overall 5-year survival in HNC patients submitted to surgery as their initial treatment and to assess the prognostic accuracy of nutritional anthropometric measurements weight loss percentage (%WL), body mass index (BMI), triceps skinfold (TSF), adductor pollicis muscle thickness (APMT), and calf circumference (CC) to predict survival in this population.
A prospective cohort study of HNC patients treated at a cancer referral center in Bahia's countryside was conducted.
Seventy-eight patients were included in this study and were followed up for a 5-year period, with an overall survival rate of 52.1%. Most patients were male (83.3%), with a median age of 65.5 years [55-72 years], and most had low education levels, low household income, and a lifestyle marked by alcohol drinking and tobacco smoking. Median values of all nutritional anthropometric variables assessed in this study were significantly lower among patients who died during follow-up, suggesting greater impairment of nutritional status in this group. All nutritional indicators were found to be predictors of survival in the study population, with a prognostic accuracy of 74% for TSF 95% CI [0.63-0.83], 68% for BMI 95% CI [0.56-0.78], 65% for CC 95% CI [0.53-0.75], 63% for APMT 95% CI [0.51-0.63], and 63% for %WL 95% CI [0.51-0.73].
The overall 5-year survival rate was found to be 52.1%, and all nutritional anthropometric variables, namely BMI, %WL, TSF, APMT, and CC, were found to be good predictors of survival in HNC patients initially treated with surgery.
已知头颈癌（HNC）患者存在较高的营养风险和营养不良患病率。头颈癌的诊断以及癌症治疗的后遗症和其他后果直接影响生存率。
确定接受手术作为初始治疗的头颈癌患者的总体5年生存率，并评估营养人体测量指标体重减轻百分比（%WL）、体重指数（BMI）、肱三头肌皮褶厚度（TSF）、拇内收肌厚度（APMT）和小腿围度（CC）预测该人群生存率的预后准确性。
对在巴伊亚州农村的一家癌症转诊中心接受治疗的头颈癌患者进行了一项前瞻性队列研究。
本研究纳入了78例患者，并进行了为期5年的随访，总体生存率为52.1%。大多数患者为男性（83.3%），中位年龄为65.5岁[55 - 72岁]，大多数患者教育水平低、家庭收入低，且生活方式以饮酒和吸烟为特征。在本研究中评估的所有营养人体测量变量的中位值在随访期间死亡的患者中显著较低，表明该组营养状况受损更严重。所有营养指标均被发现是研究人群生存率的预测因素，TSF的预后准确性为74%，95%CI[0.63 - 0.83]；BMI为68%，95%CI[0.56 - 0.78]；CC为65%，95%CI[0.53 - 0.75]；APMT为63%，95%CI[0.51 - 0.63]；%WL为63%，95%CI[0.51 - 0.73]。
发现总体5年生存率为52.1%，所有营养人体测量变量，即BMI、%WL、TSF、APMT和CC，均被发现是初始接受手术治疗的头颈癌患者生存率的良好预测因素。
