Universidade Estadual de Feira de Santana (UEFS), Feira de Santana, BA, Brazil.
Hospital Otorrinos/Multclin, Feira de Santana, BA, Brazil.
Braz J Otorhinolaryngol. 2024 Nov-Dec;90(6):101482. doi: 10.1016/j.bjorl.2024.101482. Epub 2024 Aug 5.
To evaluate the ability of the variables Muscle Mass percentage (%MM), Body Fat percentage (%BF), Phase Angle (PhA), and Standardized Phase Angle (SPhA) to predict overall survival rates in individuals with surgically treated HNC.
A prospective cohort study of surgically treated HNC patients was carried out between 2017 and 2022 at a cancer referral center in Feira de Santana, Bahia. All subjects were seen by an experienced dietitian the week before surgery. During this visit, patients had their sociodemographic and clinical data collected, as well as anthropometric measurements (weight and height) and BIA variables. In this study, postoperative overall 5-year survival was defined as the time in months between the date of surgery and the date of death, regardless of the cause of death. Patients were followed up after surgery until death.
Seventy-eight older adult patients were consecutively included. Patients had a median age of 65.5-years, were mostly men (83.3%), and most had low education levels (62.3%) and low household income, ranging from zero (19.2%) to the minimum wage (60.2%). They were mostly alcohol drinkers (91%) and tobacco smokers (87.2%). Glottic cancer was diagnosed in 48.7% of patients, with 44.8% of cases with stage-IV disease. Forty (51.2%) deaths were recorded in the follow-up period, with a median survival time of 39 months. Variables %MM, %BF, and SPhA were not significantly different between groups (alive vs. dead patients). PhA was considered an independent predictor of overall survival, with an accuracy of 69% (95% CI 0.57‒0.80). When comparing survival curves, patients with a preoperative PhA < 6.8° were more than twice as likely to die during follow-up (HR = 2.38; p = 0.02; 95% CI 1.14‒4.97).
Out of the assessed BIA variables, preoperative PhA was considered a good predictor of overall survival after HNC surgery.
评估肌肉百分比（%MM）、体脂百分比（%BF）、相位角（PhA）和标准化相位角（SPhA）等变量预测接受手术治疗的头颈部癌症（HNC）患者总生存率的能力。
这是一项在巴伊亚州费拉迪圣安娜癌症转诊中心进行的、针对接受手术治疗的 HNC 患者的前瞻性队列研究。所有患者在手术前一周都由经验丰富的营养师进行检查。在此期间，收集患者的社会人口统计学和临床数据，以及人体测量学测量（体重和身高）和 BIA 变量。在这项研究中，术后 5 年总生存率定义为从手术日期到死亡日期的月数，无论死亡原因如何。患者在手术后接受随访，直至死亡。
共连续纳入 78 名老年患者。患者的中位年龄为 65.5 岁，大多数为男性（83.3%），大多数受教育程度较低（62.3%），家庭收入较低，范围从 0（19.2%）到最低工资（60.2%）。他们大多是酒精饮用者（91%）和烟草吸烟者（87.2%）。诊断为声门型癌症的患者占 48.7%，其中 44.8%的病例为 IV 期疾病。在随访期间记录了 40（51.2%）例死亡，中位生存时间为 39 个月。%MM、%BF 和 SPhA 等变量在存活组和死亡组之间无显著差异。PhA 被认为是总生存率的独立预测因素，准确率为 69%（95%CI 0.57-0.80）。在比较生存曲线时，术前 PhA < 6.8°的患者在随访期间死亡的可能性是两倍多（HR=2.38；p=0.02；95%CI 1.14-4.97）。
在评估的 BIA 变量中，术前 PhA 被认为是预测 HNC 手术后总生存率的一个较好指标。
