Cai Yuting, Tan Yun, Cao Jian, Zhou Xiaoyuan, Li Xingyuan, Li Jianghua, Liu Chuntai, Zhang Yi, Li Yun
Department of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Adv Sci (Weinh). 2025 Sep;12(36):e13455. doi: 10.1002/advs.202413455. Epub 2025 Jun 30.
Developing an ideal vitreous substitute remains a significant challenge in ophthalmic surgery. This study introduces a novel dual-crosslinked betaine-based amphiphilic polymer hydrogel (BAPHs) synthesized via in situ free radical copolymerization. The resulting BAPHs exhibit tunable viscoelasticity, intrinsic self-healing property, injectability, stable micromorphology, and optical transparency, all modifiable by adjusting the chemical cross-linker content. When tested in a vitrectomized rabbit model, the BAPHs demonstrated optimal optical properties, mechanical stability, and promising biocompatibility. These results suggest that the BAPHs offer a transformative approach to vitreous substitution, with the potential to overcome the limitations of current clinical materials, offering both structural and functional benefits.
开发一种理想的玻璃体替代物仍然是眼科手术中的一项重大挑战。本研究介绍了一种通过原位自由基共聚合成的新型双交联甜菜碱基两亲聚合物水凝胶（BAPHs）。所得的BAPHs表现出可调节的粘弹性、固有的自愈特性、可注射性、稳定的微观形态和光学透明度，所有这些都可以通过调整化学交联剂的含量来改变。在玻璃体切除的兔模型中进行测试时，BAPHs表现出最佳的光学性能、机械稳定性和良好的生物相容性。这些结果表明，BAPHs为玻璃体替代提供了一种变革性方法，有可能克服当前临床材料的局限性，提供结构和功能上的益处。
