Rhaddioui Mehdi, Bisdorff Alexandre
Department of Neurology, University of Luxembourg, Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg.
Clinique du Vertige, Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg.
J Vestib Res. 2025 Nov;35(6):328-335. doi: 10.1177/09574271251351939. Epub 2025 Jun 30.
We report a case of paroxysmal downbeat nystagmus, ataxia, and dysarthria in the context of a delirium in a patient with severe hypomagnesemia. Extensive workup did not provide alternative explanations. Her attacks subsided within 48 h after the start of magnesium substitution and the patient remained confused and ataxic with a gradual but full recovery over 6 weeks. Hypomagnesemia resulted most probably from long-term proton-pump inhibitor (PPI) intake. Paroxysmal downbeat nystagmus is rare and has so far only been consistently described in association with hypomagnesemia of various causes.
我们报告了一例患有严重低镁血症的患者，在谵妄状态下出现阵发性下跳性眼球震颤、共济失调和构音障碍。全面检查未发现其他解释。在开始补充镁后的48小时内，她的发作症状消退，但患者仍处于意识模糊和共济失调状态，6周后逐渐完全康复。低镁血症很可能是长期服用质子泵抑制剂（PPI）所致。阵发性下跳性眼球震颤很少见，迄今为止仅在各种原因引起的低镁血症中得到一致描述。
