Zhu Juan, Liu Shiyao, Liu Peipei, Zhai Kefeng, Liu Hao
School of Pharmacy, Bengbu Medical University, No.2600, Donghai Avenue, Bengbu, 233030, Anhui, China.
Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu Medical University, Bengbu, 233030, Anhui, China.
J Nat Med. 2025 Jun 30. doi: 10.1007/s11418-025-01927-1.
Dichroa febrifuga Lour., a traditional Chinese medicinal herb historically used for malaria treatment, contains the active compound Febrifugine. Through structural modification, Halofuginone was semi-synthesized, retaining antimalarial activity with reduced toxicity. Recent studies reveal Halofuginone's broad biologic activities, including significant therapeutic potential in autoimmune diseases. By modulating abnormal immune responses, suppressing inflammation, and exerting antifibrotic effects, Halofuginone alleviates symptoms and prevents tissue damage in these conditions. This review comprehensively summarizes advances in Halofuginone research for autoimmune diseases and discusses key challenges in this field.
常山，一种历史上用于治疗疟疾的传统中草药，含有活性化合物常山碱。通过结构修饰，半合成了卤夫酮，其保留了抗疟活性且毒性降低。最近的研究揭示了卤夫酮具有广泛的生物学活性，包括在自身免疫性疾病中具有显著的治疗潜力。通过调节异常免疫反应、抑制炎症以及发挥抗纤维化作用，卤夫酮可缓解这些疾病的症状并防止组织损伤。本综述全面总结了卤夫酮在自身免疫性疾病研究方面的进展，并讨论了该领域的关键挑战。
