Yang Fangjun, Hou Dong, Wen Jiantao
Department of Orthopedic, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China.
School of Integrated Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Medicine (Baltimore). 2025 Jun 27;104(26):e43125. doi: 10.1097/MD.0000000000043125.
The ketogenic diet (KD) is a dietary regimen characterized by high-fat, moderate-protein, and extremely low-carbohydrate intake. While clinically established as an effective therapy for epilepsy and various metabolic and neurological disorders, its application presents unique challenges in surgical patients requiring perioperative maintenance of ketosis.
This report details the multidisciplinary management of a 12-year-old girl who was treated with KD for epilepsy for 10 years, who underwent posterior spinal fusion for scoliosis. At the same time, the need for perioperative care for KD-dependent pediatric patients undergoing complex procedures was also highlighted.
Imaging features showed scoliosis. The previous medical history indicates 10 years of KD treatment for epilepsy, intellectual disability for 10 years, and autism for 5 years.
The patient underwent spinal orthopedic surgery after real-time metabolic monitoring (blood glucose/ketone body detection) combined with a tailor-made anesthesia regimen.
The scoliosis surgery was carried out smoothly, no abnormal conditions occurred during the perioperative period.
Maintenance of ketosis is critical throughout the perioperative period to prevent complications including hypoglycemia, seizures, surgical failure, or even mortality in severe cases. At the same time, the use of carbohydrate-free lipid infusion and propofofo-based anesthesia during fasting avoided inadvertent carbohydrate exposure, demonstrating adaptability to perioperative period.
生酮饮食(KD)是一种以高脂肪、适量蛋白质和极低碳水化合物摄入为特征的饮食方案。虽然在临床上已被确立为治疗癫痫以及各种代谢和神经疾病的有效疗法,但其应用在需要围手术期维持酮症的外科手术患者中带来了独特的挑战。
本报告详细介绍了一名12岁女孩的多学科管理情况,该女孩因癫痫接受生酮饮食治疗10年,因脊柱侧弯接受了后路脊柱融合术。同时,也强调了依赖生酮饮食的儿科患者在接受复杂手术时围手术期护理的必要性。
影像学特征显示脊柱侧弯。既往病史表明癫痫接受生酮饮食治疗10年,智力残疾10年,自闭症5年。
患者在实时代谢监测(血糖/酮体检测)结合量身定制的麻醉方案后接受了脊柱矫形手术。
脊柱侧弯手术顺利进行,围手术期未出现异常情况。
在整个围手术期维持酮症对于预防并发症至关重要,这些并发症包括低血糖、癫痫发作、手术失败,在严重情况下甚至包括死亡。同时,禁食期间使用无碳水化合物脂质输注和基于丙泊酚的麻醉避免了意外的碳水化合物暴露,证明了对围手术期的适应性。