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体外循环相关急性肺损伤机制的研究进展与趋势：一篇叙述性综述

The progress and trends of the mechanism of cardiopulmonary bypass-associated acute lung injury: A narrative review.

作者信息

Gao Hang, Yi Tingting, Hu Bo, Lv Zhiquan, Ma Linyu, Wang Shouyong

机构信息

Department of Anesthesiology of the People's Hospital of Yongchuan District, Chongqing, China.

Department of Anesthesiology of the Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Medicine (Baltimore). 2025 Jun 27;104(26):e43019. doi: 10.1097/MD.0000000000043019.

DOI:10.1097/MD.0000000000043019
PMID:40587734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12212844/
Abstract

Studies into the mechanisms of cardiopulmonary bypass-associated acute lung injury have not presented breakthroughs for many years, resulting in the stagnation of management strategies and clinical medicine measures. This is a key factor affecting the prognoses of open-heart surgery patients. Future studies should focus on key targets of inflammation, such as neutrophils, macrophages, and the glycocalyx cell coat, and further explore advanced technologies, such as gene editing and single-cell sequencing, to reveal the underlying mechanisms of cardiopulmonary bypass-associated acute lung injury and to find effective prevention and treatment strategies.

摘要

多年来，对体外循环相关急性肺损伤机制的研究一直没有取得突破，导致管理策略和临床医学措施停滞不前。这是影响心脏直视手术患者预后的关键因素。未来的研究应聚焦于炎症的关键靶点，如中性粒细胞、巨噬细胞和糖萼细胞衣，并进一步探索基因编辑和单细胞测序等先进技术，以揭示体外循环相关急性肺损伤的潜在机制，并找到有效的预防和治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca89/12212844/6387a3376263/medi-104-e43019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca89/12212844/16804b92c3f6/medi-104-e43019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca89/12212844/6387a3376263/medi-104-e43019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca89/12212844/16804b92c3f6/medi-104-e43019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca89/12212844/6387a3376263/medi-104-e43019-g002.jpg

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Int J Mol Sci. 2022 Dec 23;24(1):277. doi: 10.3390/ijms24010277.
2
Locally organised and activated Fth1 neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner.局部组织和激活的 Fth1 中性粒细胞以依赖 IL-10 的方式加重急性肺损伤的炎症。
Nat Commun. 2022 Dec 13;13(1):7703. doi: 10.1038/s41467-022-35492-y.
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The role of lung macrophages in acute respiratory distress syndrome.
肺巨噬细胞在急性呼吸窘迫综合征中的作用。
Inflamm Res. 2022 Dec;71(12):1417-1432. doi: 10.1007/s00011-022-01645-4. Epub 2022 Oct 20.
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Biology of lung macrophages in health and disease.肺巨噬细胞在健康和疾病中的生物学作用。
Immunity. 2022 Sep 13;55(9):1564-1580. doi: 10.1016/j.immuni.2022.08.010.
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Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment.间充质干细胞调控巨噬细胞极化的研究进展及其在 ALI/ARDS 治疗中的意义。
Front Immunol. 2022 Jul 8;13:928134. doi: 10.3389/fimmu.2022.928134. eCollection 2022.
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Immunol Lett. 2022 Jan;241:23-34. doi: 10.1016/j.imlet.2021.10.008. Epub 2021 Nov 2.
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