1990 - 2021年帕金森病负担：2021年全球疾病负担研究的系统分析 - Suppr

The burden of Parkinson's disease, 1990-2021: a systematic analysis of the Global Burden of Disease study 2021.

作者信息

Wu Xi-Chen, Dong Yi-Yue, Ying Yu-Chen, Chen Guang-Yan, Fan Qian, Yin Ping, Chen Yue-Lai

机构信息

LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Gansu Provincial People's Hospital, Lanzhou, China.

出版信息

Front Aging Neurosci. 2025 Jun 16;17:1596392. doi: 10.3389/fnagi.2025.1596392. eCollection 2025.

BACKGROUND

The pathogenesis of Parkinson's disease (PD) remains incompletely understood, has drawn significant attention within the scope of the Global Burden of Disease (GBD) study. Therefore, to explore PD's global burden and devise countermeasures is indispensable.

METHODS

Data from GBD 2021 to analyze age standardized incidence rate (ASIR), prevalence rate (ASPR), mortality rate (ASMR), and disability adjusted life years (DALYs) rate (ASDR) burden of PD globally. Moreover, the estimated annual percentage change (EAPC) was utilized to gauge PD burden trends from 1990 to 2021. Subsequently, PD burden by sex and 21 GBD regions was further evaluated in 2021. Moreover, the influence of age, sex, and socio-demographic index (SDI) on burden of PD from 1990 to 2021 was examined. Finally, the projection of burden of PD from 2022 to 2026 was also conducted.

RESULTS

From 1990 to 2021, ASIR, ASPR, and ASDR were shown to be on an upward trend for both males and females. However, ASMR was higher in males than in females. In addition, ASIR, ASPR, and ASDR in the East Asian region were found to be the highest, and they were higher among males than among females. Notably, with the elapse of years, PD's total incidence cases, prevalence cases, mortality cases, and DALYs cases were all presented with an upward trend. Moreover, in 1990 and 2021, ASDR in 75-79 age group was the highest. Finally, from 2022 to 2026, PD's ASIR and ASPR were predicted to exhibit an upward tendency, while ASMR and ASDR were expected to show a downward trend.

CONCLUSION

The research showed a growing global ASIR and ASPR of PD over time, urging more effective health policies to ease its burden.

背景

帕金森病（PD）的发病机制仍未完全明确，在全球疾病负担（GBD）研究范围内受到了广泛关注。因此，探索帕金森病的全球负担并制定应对措施至关重要。

方法

利用全球疾病负担研究（GBD）2021的数据，分析全球帕金森病的年龄标准化发病率（ASIR）、患病率（ASPR）、死亡率（ASMR）和伤残调整生命年（DALYs）率（ASDR）负担。此外，采用估计年度百分比变化（EAPC）来衡量1990年至2021年帕金森病负担的趋势。随后，进一步评估了2021年按性别和21个全球疾病负担区域划分的帕金森病负担。此外，还研究了1990年至2021年年龄、性别和社会人口指数（SDI）对帕金森病负担的影响。最后，还对2022年至2026年帕金森病负担进行了预测。

结果

1990年至2021年，男性和女性的年龄标准化发病率、患病率和伤残调整生命年率均呈上升趋势。然而，男性的死亡率高于女性。此外，东亚地区的年龄标准化发病率、患病率和伤残调整生命年率最高，且男性高于女性。值得注意的是，随着时间的推移，帕金森病的总发病例数、患病例数、死亡病例数和伤残调整生命年病例数均呈上升趋势。此外，1990年和2021年，75-79岁年龄组的伤残调整生命年率最高。最后，预计2022年至2026年，帕金森病的年龄标准化发病率和患病率将呈上升趋势，而死亡率和伤残调整生命年率将呈下降趋势。