1990年至2021年中国青年成年人痛风负担的系统分析：全球疾病负担研究2021的结果

Systematic analysis of gout burden among young adults in China from 1990 to 2021: findings from the global burden of disease study 2021.

作者信息

Zhong Yuxin, Li Yan, Hu Chenyu, Tao Tao, Hao Liyuan, Li Na, Zeng Xiaoyan, Zhang Zixin, Hu Xiaoyu

机构信息

Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Department of Stomach (Gastroenterology), Nantong Hospital of Traditional Chinese Medicine, Nantong, China.

出版信息

Front Public Health. 2025 Jun 9;13:1613801. doi: 10.3389/fpubh.2025.1613801. eCollection 2025.

DOI:10.3389/fpubh.2025.1613801

PMID:40552223

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12183959/

Abstract

BACKGROUND

Gout, a disabling inflammatory arthritis, closely linked to metabolic diseases such as hyperuricemia, obesity, hypertension, and diabetes, is increasingly prevalent among young adults in China. Understanding the burden of gout and its risk factors among young adults in China is crucial for developing effective prevention and management strategies.

METHODS

We analyzed data from the Global Burden of Disease Study 2021 (GBD 2021) on gout prevalence, incidence, and disability-adjusted life years (DALYs) among young adults (individuals aged 15-39 years) in China from 1990 to 2021. Joinpoint regression and the AutoRegressive Integrated Moving Average (ARIMA) model were used to assess trends and predict future burden. Summary exposure values (SEVs) were used to evaluate risk factors.

RESULTS

The study found that the burden of gout among young adults in China is significantly higher than the global average and shows a continuous upward trend. Males have a higher burden and age-standardized rates on all indicators, including prevalence, incidence, and DALYs. Joinpoint regression analysis revealed that from 1990 to 2021, the burden of gout has experienced rapid growth, stabilization, and a resurgence of acceleration since 2019. ARIMA model projects different epidemiological trends for gout across 2022-2036, with age-standardized prevalence rate (ASPR) and age-standardized incidence rate (ASIR) declining while age-standardized DALYs rate (ASDR) gradually rise. Gender-specific disparities persist. Females demonstrate a predictable rise in ASPR, ASIR and ASDR. Despite males facing higher baseline burdens and accelerating ASDR growth, their ASPR and ASIR exhibit downward trends. A significant rise in gout risk factors among Chinese aged 15-39 from 1990 to 2021 highlights the need to face the upcoming gout burden and carry out targeted measures for this population.

CONCLUSION

The rising burden of gout among young Chinese adults demands immediate gender- and age-specific public health action. Targeted interventions focusing on modifiable risk factors such as dietary habits and lifestyle are crucial to reduce the impact of gout on young adults.

摘要

背景

痛风是一种使人致残的炎症性关节炎，与高尿酸血症、肥胖、高血压和糖尿病等代谢性疾病密切相关，在中国年轻人中日益普遍。了解中国年轻人痛风的负担及其风险因素对于制定有效的预防和管理策略至关重要。

方法

我们分析了《2021年全球疾病负担研究》（GBD 2021）中1990年至2021年中国年轻人（15至39岁个体）痛风患病率、发病率和伤残调整生命年（DALYs）的数据。采用Joinpoint回归和自回归积分移动平均（ARIMA）模型评估趋势并预测未来负担。使用汇总暴露值（SEVs）评估风险因素。

结果

研究发现，中国年轻人痛风负担显著高于全球平均水平，且呈持续上升趋势。男性在所有指标（包括患病率、发病率和伤残调整生命年）上的负担和年龄标准化率更高。Joinpoint回归分析显示，1990年至2021年期间，痛风负担经历了快速增长、稳定阶段，自2019年起又重新加速上升。ARIMA模型预测了2022年至2036年痛风的不同流行病学趋势，年龄标准化患病率（ASPR）和年龄标准化发病率（ASIR）下降，而年龄标准化伤残调整生命年率（ASDR）逐渐上升。性别差异依然存在。女性的年龄标准化患病率、发病率和伤残调整生命年率呈现可预测的上升趋势。尽管男性面临更高的基线负担且年龄标准化伤残调整生命年率加速增长，但其年龄标准化患病率和发病率呈下降趋势。1990年至2021年期间，中国15至39岁人群痛风风险因素显著增加，这凸显了应对即将到来的痛风负担并针对该人群采取针对性措施的必要性。