Wu Zongzhou, Liang Xinlin, Yu Qian, Zhang Wei, Shi Yuling
Department of Medical Cosmetology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China.
J Cosmet Dermatol. 2025 Jul;24(7):e70322. doi: 10.1111/jocd.70322.
Fractional CO laser is commonly used for various skin issues but often causes side effects like erythema, hyperpigmentation, and prolonged recovery, negatively impacting patients' quality of life.
This study evaluates the effect of hyaluronic acid (HA) dressings with different molecular weights (large: medium: low = 2:2:1) on skin barrier repair after CO fractional laser treatment, providing clinical evidence for post-procedural skincare.
In this prospective, randomized, open-label, controlled trial, patients aged 19-45 who underwent CO fractional laser treatment were randomly assigned to either the hyaluronic acid (HA) group (Group A) or the control group (Group B). The primary endpoint was transepidermal water loss (TEWL) at day 14. Secondary endpoints included erythema index (EI), melanin index (MI), skin hydration, semi-quantitative acute inflammatory response scores (erythema, burning sensation, edema), erythema duration, edema duration, pain duration, scab shedding time, and overall patient satisfaction on day 14.
A total of 60 patients were included. On day 14, the TEWL in Group A was significantly lower than in Group B (16.69 vs. 19.79, p = 0.009), and the percentage change in TEWL during the period of the most significant reduction was also greater in Group A than in Group B (-75.10% vs. -70.89%, p = 0.042). The EI in Group A were significantly lower than those in Group B on days 3, 7, and 14 (325.41 vs. 370.83, p = 0.038; 297.77 vs. 338.32, p = 0.041; 287.14 vs. 337.38, p = 0.004). The pain duration in Group A was also significantly shorter than in Group B (0.20 vs. 0.53, p = 0.014). In addition, Group A patients reported higher satisfaction scores on the post-treatment questionnaires.
This study highlights hyaluronic acid with varied molecular sizes enhances post-laser recovery by reducing TEWL and erythema, alleviating pain, and promoting healing.
剥脱性二氧化碳激光常用于治疗各种皮肤问题，但常引发红斑、色素沉着和恢复时间延长等副作用，对患者生活质量产生负面影响。
本研究评估不同分子量（大：中：小 = 2:2:1）透明质酸（HA）敷料对二氧化碳剥脱性激光治疗后皮肤屏障修复的效果，为术后皮肤护理提供临床依据。
在这项前瞻性、随机、开放标签、对照试验中，将接受二氧化碳剥脱性激光治疗的19 - 45岁患者随机分为透明质酸（HA）组（A组）和对照组（B组）。主要终点是第14天的经表皮水分流失（TEWL）。次要终点包括红斑指数（EI）、黑色素指数（MI）、皮肤水合作用、半定量急性炎症反应评分（红斑、灼痛、水肿）、红斑持续时间、水肿持续时间、疼痛持续时间、结痂脱落时间以及第14天患者的总体满意度。
共纳入60例患者。在第14天，A组的TEWL显著低于B组（16.69对19.79，p = 0.009），且在TEWL下降最显著期间，A组TEWL的百分比变化也大于B组（-75.10%对-70.89%，p = 0.042）。在第3天、第7天和第14天，A组的EI显著低于B组（325.41对370.83，p = 0.038；297.77对338.32，p = 0.041；287.14对337.38，p = 0.004）。A组的疼痛持续时间也显著短于B组（0.20对0.53，p = 0.014）。此外，A组患者在治疗后问卷中的满意度得分更高。
本研究表明，不同分子大小的透明质酸通过降低TEWL和红斑、减轻疼痛以及促进愈合，可增强激光治疗后的恢复效果。
