Gao Meiyan, Gao Ni, Wang Li, Yao Ting, Jing Huan, Liu Hui, Gao Lin
Department of Dermatology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
J Cosmet Dermatol. 2025 Jul;24(7):e70223. doi: 10.1111/jocd.70223.
Facial laser procedures may result in compromised skin barrier function and associated discomfort. It is essential to address these issues to facilitate a swift recovery and enhance patient satisfaction.
To evaluate the efficacy and safety of a panthenol-enriched mask, incorporating centella asiatica extract (madecassoside) and bisabolol, in repairing the skin barrier after 1550 and 1927 nm dual-wavelength non-ablative fractional laser therapy.
A total of 60 subjects were enrolled in this double-blind randomized study and were divided into Control group (CG) and Mask group (MG). Both groups received standard post-operative care, the MG receiving the Mask, while the CG received a saline dressing. Skin barrier repair was assessed using a skin physiological detection instrument, colorimetry, and a skin imaging analyzer (VISIA). The incidence of adverse reactions was also monitored.
The MG exhibited significantly lower erythema index and hyperpigmentation index at D3, D7, and D14, compared to the CG. The MG had significantly higher sebum content than the CG at D7 and D14. The stratum corneum moisture content in the MG was also higher than in the CG at D3, D7, and D14. Additionally, transepidermal water loss (TEWL) was significantly reduced in the MG at D3, D7, and D14. There was no significant difference in the rate of adverse reactions between the groups.
A panthenol-enriched Mask effectively decreased post non-ablative laser erythema, enhanced skin hydration, and promoted skin barrier repair.
面部激光手术可能导致皮肤屏障功能受损及相关不适。解决这些问题对于促进快速恢复和提高患者满意度至关重要。
评估一种富含泛醇，并含有积雪草提取物（羟基积雪草苷）和红没药醇的面膜，在1550和1927纳米双波长非剥脱性点阵激光治疗后修复皮肤屏障的有效性和安全性。
本双盲随机研究共纳入60名受试者，分为对照组（CG）和面膜组（MG）。两组均接受标准术后护理，MG组使用该面膜，而CG组使用生理盐水敷料。使用皮肤生理检测仪器、比色法和皮肤成像分析仪（VISIA）评估皮肤屏障修复情况。同时监测不良反应的发生率。
与CG组相比，MG组在第3天、第7天和第14天的红斑指数和色素沉着指数显著更低。MG组在第7天和第14天的皮脂含量显著高于CG组。MG组在第3天、第7天和第14天的角质层水分含量也高于CG组。此外，MG组在第3天、第7天和第14天的经表皮水分流失（TEWL）显著降低。两组之间的不良反应发生率无显著差异。
富含泛醇的面膜可有效减轻非剥脱性激光术后红斑，增强皮肤水合作用，并促进皮肤屏障修复。
