Department of Medical Cosmetology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
J Eur Acad Dermatol Venereol. 2024 Jul;38 Suppl 6:17-25. doi: 10.1111/jdv.20070. Epub 2024 Jun 3.
Ablative fractional CO laser is widely used to address various skin problems, but the treatment often leads to adverse effects such as erythema, dyspigmentation, and extended recovery periods, negatively impacting patients' quality of life.
This study aimed to evaluate the efficacy and safety of a topical skincare regimen containing both CE Ferulic serum and Resveratrol BE night serum following fractional CO laser treatment in Chinese population.
In this randomized, investigator-blinded, split-face, controlled trial, individuals aged 18-65 undergoing ablative CO laser treatment were randomly assigned to apply CE Ferulic plus resveratrol BE serum (CEF-RBE) to either side of face and normal saline (NS) to the other, for 14 consecutive days. The primary endpoint was erythema index (EI) on day 14, with key secondary endpoints including scabbing detachment time, percentage changes in EI and melanin index (MI), skin hydration, transepidermal water loss, skin sebum content, oedema, and overall subject satisfaction.
The study included 51 patients, of whom 29 (56.9%) were female, with a mean (SD) age of 29.8 (5.39) years. On day 14, the CEF-RBE side exhibited significantly lower EI than the NS side (308.9 vs. 325.3, p = 0.034). The median (IQR) time (days) for complete scabbing detachment at the CEF-RBE side was 6.0 (5.0-8.0) compared to 6.5 (5.0-9.0) at NS side (p = 0.018). Additionally, the CEF-RBE side showed a 7.4% decrease in MI from baseline to day 14, while the NS side experienced a 0.2% increase (Δ = -7.6%, p = 0.044). Throughout the 14-day follow-up, the CEF-RBE side consistently displayed higher skin hydration than the NS side.
The study highlighted the benefits of incorporating CEF-RBE following laser treatment in reducing erythema and hyperpigmentation, promoting wound healing, and maintaining skin hydration, although limitations such as contamination and adherence issues should be considered.
剥脱性点阵 CO2 激光被广泛应用于解决各种皮肤问题，但治疗通常会导致红斑、色素沉着不均和恢复期延长等不良反应，从而降低患者的生活质量。
本研究旨在评估在中国人群中，使用 CE 富勒醇精华液和 Resveratrol BE 夜用精华液的局部护肤方案在接受剥脱性 CO2 激光治疗后的疗效和安全性。
在这项随机、研究者盲法、左右半脸对照、对照的临床试验中，18-65 岁接受剥脱性 CO2 激光治疗的个体被随机分配到使用 CE 富勒醇加白藜芦醇 BE 血清（CEF-RBE）的一侧和使用生理盐水（NS）的另一侧，连续 14 天。主要终点是第 14 天的红斑指数（EI），关键次要终点包括结痂脱落时间、EI 和黑色素指数（MI）变化百分比、皮肤水分、经表皮水分流失、皮肤皮脂含量、水肿和整体患者满意度。
该研究纳入了 51 名患者，其中 29 名（56.9%）为女性，平均（SD）年龄为 29.8（5.39）岁。第 14 天，CEF-RBE 侧的 EI 明显低于 NS 侧（308.9 比 325.3，p=0.034）。CEF-RBE 侧的结痂完全脱落的中位数（IQR，天）为 6.0（5.0-8.0），而 NS 侧为 6.5（5.0-9.0）（p=0.018）。此外，CEF-RBE 侧从基线到第 14 天 MI 下降了 7.4%，而 NS 侧仅增加了 0.2%（Δ=-7.6%，p=0.044）。在整个 14 天的随访中，CEF-RBE 侧的皮肤水分始终高于 NS 侧。
该研究表明，在激光治疗后使用 CEF-RBE 可以减少红斑和色素沉着过度，促进伤口愈合和保持皮肤水分，尽管存在污染和依从性等问题，但具有一定的益处。
