Wang Yinuo, Li Xiaobing, Liu Min, Xu Xiaoxu, Ma Yue, Luo Yang, Wang Yue
Medical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Department of Human Anatomy, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Int J Neuropsychopharmacol. 2025 Jul 23;28(7). doi: 10.1093/ijnp/pyaf044.
More than 100 types of RNA modifications have been identified in mammalian cells, among which N6-methyladenosine (m6A) is the most prevalent. This reversible and dynamic modification involves methyltransferases, demethylases, and reader proteins. Aberrant expression of m6A-related regulatory proteins in the nervous system significantly impacts neuronal physiology, contributing to mental disorders such as depression, autism spectrum disorder, and schizophrenia. This review summarizes the role of m6A methylation in the pathogenesis of mental disorders and highlights its potential as a biomarker and therapeutic target, providing a comprehensive reference for future research and clinical interventions.
在哺乳动物细胞中已鉴定出100多种RNA修饰类型，其中N6-甲基腺苷（m6A）最为普遍。这种可逆的动态修饰涉及甲基转移酶、去甲基酶和阅读蛋白。m6A相关调节蛋白在神经系统中的异常表达会显著影响神经元生理功能，导致抑郁症、自闭症谱系障碍和精神分裂症等精神疾病。本综述总结了m6A甲基化在精神疾病发病机制中的作用，并强调了其作为生物标志物和治疗靶点的潜力，为未来的研究和临床干预提供了全面的参考。
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