Qin Qiaozhen, Ruan Huaqiang, Zhang Heyang, Xu Zhenhua, Pan Wenting, Yan Xinlong, Jiang Xiaoxia
Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing Key Laboratory of Environmental and Viral Oncology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.
Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Int J Mol Sci. 2024 Dec 4;25(23):13051. doi: 10.3390/ijms252313051.
MYSM1, a deubiquitinating enzyme, plays a pivotal role in diverse biological processes. Both MYSM1 knockout mice and patients with Mysm1 gene mutations exhibit developmental abnormalities across multiple tissues and organs. Serving as a crucial regulator, MYSM1 influences stem cell function, immune responses, and the pathogenesis of diverse diseases. This review comprehensively details MYSM1's deubiquitinating activities in both the nucleus and cytoplasmic compartments, its effects on stem cell proliferation, differentiation, and immune cell function, and its involvement in cancer, aging, and depression. The high sequence homology between murine and human MYSM1, along with similar phenotypes observed in Mysm1-deficient models, provides valuable insights into the etiology of human Mysm1-deficiency syndromes. This review aims to offer a foundation for future comprehensive research on MYSM1.
MYSM1是一种去泛素化酶，在多种生物学过程中发挥关键作用。MYSM1基因敲除小鼠和携带Mysm1基因突变的患者在多个组织和器官中均表现出发育异常。作为一个关键调节因子，MYSM1影响干细胞功能、免疫反应以及多种疾病的发病机制。本综述全面详细地阐述了MYSM1在细胞核和细胞质区室中的去泛素化活性、其对干细胞增殖、分化和免疫细胞功能的影响，以及其在癌症、衰老和抑郁症中的作用。小鼠和人类MYSM1之间的高度序列同源性，以及在Mysm1缺陷模型中观察到的相似表型，为深入了解人类Mysm1缺陷综合征的病因提供了有价值的见解。本综述旨在为未来对MYSM1的全面研究奠定基础。
