Cao Yangbin, Tang Peiyuan, Tan Han, Ma Wenbo, Chai Hua, Lin Bin, Zhu Ying, Xiao Wenfeng, Wen Ting, Zhang Jun, Li Yusheng, Liu Shuguang
EFORT Open Rev. 2025 Jul 1;10(7):466-474. doi: 10.1530/EOR-2024-0167.
To evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of osteonecrosis of the femoral head (ONFH).
Search for term systems related to ONFH and HBOT in PubMed, Cochrane Library, Embase and Web of Science databases. The risk ratio (RR) was used as the effective index for dichotomous variables while mean difference (MD) and 95% confidence interval (CI) were used as the effective index for continuous variables, with a two-sided P < 0.05 considered statistically significant. I2 statistic and Q test were used to evaluate the statistical heterogeneity of the included studies.
Ten studies were included, involving 568 participants. Pre-post meta-analyses to show the visual analog scale after HBOT (MD = -2.94, 95% CI: -4.27, -1.60, P < 0.0001), short form 12 physical component summary scale (SF12 PCS) (MD = 17.28, 95% CI: 8.26, 26.31, P = 0.0002), short form 12 mental component summary scale (SF12 MCS) (MD = 4.26, 95% CI: 2.56, 5.95, P < 0.00001), Harris hip score (HHS) (MD = 26.91, 95% CI: 0.35, 53.46, P = 0.05), modified Harris hip score (mHHS) (MD = 44.31, 95% CI: 13.75, 74.87, P = 0.004) were significantly different from those before treatment. The results of SF12 PCS (MD = -0.39, 95% CI: -7.85, 7.06, P = 0.92) and SF12 MCS (MD = 0.76, 95% CI: -7.02, 8.52, P = 0.85), patients' improved events (RR = 1.83, 95% CI: 0.37, 9.09, P = 0.46) showed no significant difference between the HBO and non-HBO groups.
The results of this study indicate that HBOT cannot be regarded as an effective measure for the treatment of early-stage necrosis of the femoral head and more large-scale randomized controlled trials are needed for further verification.
评估高压氧疗法（HBOT）治疗股骨头坏死（ONFH）的有效性。
在PubMed、Cochrane图书馆、Embase和科学网数据库中搜索与ONFH和HBOT相关的术语系统。风险比（RR）用作二分变量的有效指标，而均值差（MD）和95%置信区间（CI）用作连续变量的有效指标，双侧P<0.05被认为具有统计学意义。使用I²统计量和Q检验评估纳入研究的统计异质性。
纳入10项研究，涉及568名参与者。治疗前后的荟萃分析显示，高压氧治疗后的视觉模拟量表（MD=-2.94，95%CI：-4.27，-1.60，P<0.0001）、简短健康调查12项身体成分汇总量表（SF12 PCS）（MD=17.28，95%CI：8.26，26.31，P=0.0002）、简短健康调查12项心理成分汇总量表（SF12 MCS）（MD=4.26，95%CI：2.56，5.95，P<0.00001）、Harris髋关节评分（HHS）（MD=26.91，95%CI：0.35，53.46，P=0.05）、改良Harris髋关节评分（mHHS）（MD=44.31，95%CI：13.75，74.87，P=0.004）与治疗前有显著差异。SF12 PCS（MD=-0.39，95%CI：-7.85，7.06，P=0.92）和SF12 MCS（MD=0.76，95%CI：-7.02，8.52，P=0.85）的结果，患者改善事件（RR=1.83，95%CI：0.37，9.09，P=0.46）在高压氧组和非高压氧组之间无显著差异。
本研究结果表明，高压氧疗法不能被视为治疗早期股骨头坏死的有效措施，需要更多大规模随机对照试验进行进一步验证。
