Song Jiaxuan, Liu Xiang, Yang Xu, Jiang Weibo, Cao Jiankang
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Tianjin Key Laboratory of Food Safety Monitoring Technology, National Center of Inspection and Testing for Processed Food Quality, Tianjin Institute for Food Safety Inspection Technology, Tianjin, 300308, China.
Int J Biol Macromol. 2025 Aug;319(Pt 4):145596. doi: 10.1016/j.ijbiomac.2025.145596. Epub 2025 Jun 29.
With the increasing attention on food safety and health promotion, the development of natural, non-toxic and biodegradable encapsulation materials is upcoming in food system. Cyclodextrin-based metal-organic frameworks (CD-MOFs) are promising edible MOFs currently reported, consisting of cyclodextrins and alkali metal ions with different crystal configurations and cavity sizes. CD-MOFs not only maintain advantages of common MOFs such as highly porous structure, diversified functional sites, unique host-guest interactions, but also bring the desirable features of CDs such as nontoxicity, biocompatibility, and environmental friendliness. CD-MOFs possessed good properties of internal and external hydrophilicity, adsorption and separation, and biocompatibility. The loading of active ingredients into CD-MOFs can enhance their stability, targeted delivery and controlled release. These features make CD-MOFs great potential in applications in biomedicine, chemical products, environment protection, as well as food industry. Here, the most advanced progress in the study on the structure, synthesis and physicochemical properties of CD-MOFs was introduced. Then, the current status of the application of CD-MOFs in active ingredients loading, protection, targeted delivery and slow release in food matrix were comprehensively summarized, especially the relevant reports in the past five years. The potential opportunities and prospects for the development of novel complexes with CD-MOFs are envisioned.
随着对食品安全和健康促进的关注度不断提高，食品体系中天然、无毒且可生物降解的包封材料的开发即将到来。基于环糊精的金属有机框架（CD-MOFs）是目前报道的有前景的可食用MOFs，由具有不同晶体构型和空腔尺寸的环糊精和碱金属离子组成。CD-MOFs不仅保留了普通MOFs的优点，如高度多孔的结构、多样的功能位点、独特的主客体相互作用，还带来了环糊精的理想特性，如无毒、生物相容性和环境友好性。CD-MOFs具有良好的内外亲水性、吸附和分离以及生物相容性。将活性成分负载到CD-MOFs中可以提高其稳定性、靶向递送和控释性能。这些特性使CD-MOFs在生物医学、化学产品、环境保护以及食品工业等应用中具有巨大潜力。在此，介绍了CD-MOFs在结构、合成和物理化学性质研究方面的最新进展。然后，全面总结了CD-MOFs在食品基质中活性成分负载、保护、靶向递送和缓释方面的应用现状，特别是过去五年的相关报道。展望了开发与CD-MOFs新型复合物的潜在机遇和前景。
