Himmels Jan Peter William, Magnusson Karin, Brurberg Kjetil Gundro
Norwegian Institute of Public Health, Oslo, Norway.
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden.
Nat Commun. 2025 Jul 1;16(1):5717. doi: 10.1038/s41467-025-60784-4.
The long-term effects of COVID-19, known as post-COVID condition (PCC), are still not fully understood. This systematic review synthesizes findings from Nordic registry studies to highlight long-term outcomes after COVID-19 infection. Twenty-two studies, primarily reflecting the pre-omicron and early vaccination phases, reveal increased primary care use for respiratory issues and fatigue in the sub-acute and chronic phases, with PCC incidence estimated below 2% in the general population. Most individuals returned to work within three months post-infection, and the risk of new neurological or mental disorders did not exceed that in patients with other infections. The review demonstrates the value of high-quality Nordic health registries in capturing reliable, population-wide data, though generalizability may be limited to similar healthcare systems. Findings suggest the need for targeted follow-up in patients with severe COVID-19, particularly those requiring intensive care, to manage potential new-onset diseases and guide resource allocation in the pandemic's endemic phase.
新冠病毒病的长期影响，即新冠后状况（PCC），目前仍未被完全了解。本系统评价综合了北欧登记研究的结果，以突出新冠病毒感染后的长期结局。22项主要反映了前奥密克戎和早期疫苗接种阶段的研究显示，在亚急性期和慢性期，因呼吸问题和疲劳而增加了初级保健的使用，PCC在普通人群中的发病率估计低于2%。大多数人在感染后三个月内恢复工作，新出现神经或精神障碍的风险不超过其他感染患者。该评价证明了高质量北欧健康登记在获取可靠的全人群数据方面的价值，尽管其普遍性可能仅限于类似的医疗保健系统。研究结果表明，对于重症新冠病毒病患者，尤其是那些需要重症监护的患者，需要进行有针对性的随访，以管理潜在的新发疾病，并在疫情流行阶段指导资源分配。
