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洛伐他汀晶体和非晶态形式的热容及热力学函数

Heat capacity and thermodynamic functions of crystalline and amorphous forms of Lovastatin.

作者信息

Brycka Maria, Olszewska Agata, Parkinson Natalie, Hoban Christopher, Czerniecka-Kubicka Anna, Pyda Marek, Woodfield Brian F, Skotnicki Marcin

机构信息

Industrial Pharmacy Division, Chair and Department of Pharmaceutical Technology, Poznan, University of Medical Sciences, ul. Rokietnicka 3, Poznan, 60-806, Poland.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84604, USA.

出版信息

Sci Rep. 2025 Jul 2;15(1):22464. doi: 10.1038/s41598-025-05075-0.

DOI:10.1038/s41598-025-05075-0
PMID:40592956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12217180/
Abstract

The thermal behavior of crystalline and amorphous lovastatin was studied using advanced thermal analysis, including the Quantum Design Physical Property Measurement System and Differential Scanning Calorimetry. Equilibrium lines for liquid and solid states were determined from experimental heat capacity values, allowing for the calculation of state functions. The Kauzmann temperature (T) was estimated based on enthalpy and entropy as a function of temperature. Physical ageing studies were conducted at 10 °C for various durations, from 15 min up to 72 h and fictive temperatures were determined for the aged samples. Quantitative thermal analysis provided essential thermodynamic data for both the crystalline and amorphous phases of lovastatin.

摘要

采用先进的热分析方法，包括量子设计物理性质测量系统和差示扫描量热法，研究了结晶态和非晶态洛伐他汀的热行为。根据实验热容量值确定了液态和固态的平衡线，从而能够计算状态函数。基于焓和熵随温度的变化关系估算了考兹曼温度（T）。在10℃下对不同时长（从15分钟到72小时）进行了物理老化研究，并确定了老化样品的虚构温度。定量热分析为洛伐他汀的结晶相和非晶相提供了重要的热力学数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/ac3e5039d91a/41598_2025_5075_Fig12_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/ac3e5039d91a/41598_2025_5075_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/a92c9c3caecf/41598_2025_5075_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/fdcc9708a58d/41598_2025_5075_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/6fd233d59276/41598_2025_5075_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/106fd447bde2/41598_2025_5075_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/f5ff6d489a08/41598_2025_5075_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/0182d3553b50/41598_2025_5075_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/f3ac3aceb02f/41598_2025_5075_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/c84f6dc288d5/41598_2025_5075_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/e7faa22c02f6/41598_2025_5075_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/a4c2def94017/41598_2025_5075_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/92434773c04d/41598_2025_5075_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/12217180/ac3e5039d91a/41598_2025_5075_Fig12_HTML.jpg

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