A TEMPO supported-deep eutectic solvent as a novel and capable catalyst for alcohol oxidations.

The oxidation reactions of organic functional groups are one of the important processes in synthesis and chemical industries and have wide applications. Therefore, it is very important to use suitable, cheap, biocompatible, non-toxic catalysts as well as oxidants that do not produce by-products or non-toxic by-products. In the upcoming project, we are trying to use deep eutectic solvents (DESs) containing tempo unit as an active oxidizing catalyst in alcohol oxidation. Numerous catalytic systems have been developed for the aerobic oxidation of alcohols, with TEMPO-based systems utilizing metal co-catalysts being the most extensively studied. This study introduces a novel catalytic system, namely a TEMPO-supported DES (TEMPO-DES) and Fe(NO)·9HO for the oxidation of alcohols using molecular oxygen as the terminal oxidant. The TEMPO-DES was prepared by combining salt ([Quaternium-TEMPO]Cl) with glycine. The TEMPO-DES/Fe(NO) system demonstrated excellent performance in selectively oxidizing various alcohols to their corresponding aldehydes and ketones under mild and solvent-free conditions. Furthermore, the DES could be easily recovered without experiencing significant loss of catalytic activity.