Sanchis R, Esquifino A, Guerri C
Pharmacol Biochem Behav. 1985 Aug;23(2):221-4. doi: 10.1016/0091-3057(85)90560-x.
The effect on the estrous cycle, as well as prolactin, luteinizing hormone (LH) and alcohol levels, were studied in female rats during chronic alcohol intake. Rats were fed the following diets for 5 weeks: a liquid ethanol diet (5% ethanol, w/v), an isocaloric liquid diet (pair-fed) or laboratory rat-chow and water ad lib. Ethanol-fed rats showed an irregular estrous cycle with a significant decrease in the frequency of the estrus + proestrus phases, and an increase in the duration of the diestrus + metaestrus phases, when compared with both the pair-fed and rat-chow groups. In these alcoholic rats, the estrous cycle phase was correlated with blood alcohol levels, which were found to be lower in the estrus + proestrus than in the other phases of the cycle. At the same time plasma prolactin levels were higher and plasma LH levels lower in the alcoholic rats than in either control group. These data indicate that chronic ethanol consumption prolongs the diestrus phase together with altered plasma prolactin and LH levels in female rats.
在雌性大鼠长期摄入酒精期间，研究了其对发情周期以及催乳素、促黄体生成素（LH）和酒精水平的影响。大鼠被喂食以下饮食5周：液体乙醇饮食（5%乙醇，w/v）、等热量液体饮食（配对喂食）或实验室大鼠饲料并随意饮水。与配对喂食组和大鼠饲料组相比，喂食乙醇的大鼠发情周期不规律，发情期 + 动情前期的频率显著降低，间情期 + 动情后期的持续时间增加。在这些酒精性大鼠中，发情周期阶段与血液酒精水平相关，发现在发情期 + 动情前期的血液酒精水平低于周期的其他阶段。同时，酒精性大鼠的血浆催乳素水平高于对照组，血浆LH水平低于对照组。这些数据表明，长期摄入乙醇会延长雌性大鼠的间情期，同时改变血浆催乳素和LH水平。
