Krueger W A, Bo W J, Rudeen P K
Pharmacol Biochem Behav. 1983 Oct;19(4):583-5. doi: 10.1016/0091-3057(83)90331-3.
This study is designed for better understanding the effect of chronic ethanol treatment on ovarian function in sexually mature rats by assessing the estrous cycle. Rats were fed the following diets for 17 weeks: a liquid diet containing 5% (w/v) ethanol, a liquid diet without ethanol (pair-fed) or laboratory chow and water ad lib. Estrous cycles were determined throughout the 17 weeks and the rats were necropsied at proestrus and metestrus. Ethanol-fed rats had significantly more irregular estrous cycles than did controls, and the duration of an estrous cycle in the ethanol-treated rats was statistically longer than that of controls. However, ovarian and uterine weights and ovarian and vaginal morphology of ethanol-fed rats were similar to those of controls.
本研究旨在通过评估动情周期，更好地了解慢性乙醇处理对性成熟大鼠卵巢功能的影响。大鼠被给予以下饮食17周：含5%（w/v）乙醇的液体饮食、不含乙醇的液体饮食（配对喂养）或实验室饲料并随意饮水。在整个17周内测定动情周期，并在动情前期和动情后期对大鼠进行尸检。乙醇喂养的大鼠动情周期明显比对照组更不规律，且乙醇处理大鼠的动情周期持续时间在统计学上比对照组更长。然而，乙醇喂养大鼠的卵巢和子宫重量以及卵巢和阴道形态与对照组相似。
