da Cruz Carvalho Maria Clara, Mota Ana Carolina Costa Campos, do Nascimento Daniele de Souza Marinho, de Sousa Ingrid Naihara França, Bona Mariana Duarte, da Silva Ribeiro Karla Danielly, Lima Aldo Ângelo Moreira, Maciel Bruna Leal Lima
Post Graduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil.
Post Graduate Program in Nutrition, Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil.
Sci Rep. 2025 Jul 1;15(1):21919. doi: 10.1038/s41598-025-08045-8.
Aging reduces functional capacity, decreasing lean mass and immune function, possibly impacting the intestinal morphofunctional barrier. This study aimed to characterize intestinal permeability in an elderly population and its association with anthropometric and biochemical variables associated with cardiovascular risk. A cross-sectional study was conducted with 54 elderly individuals from Oct/19-Mar/23. Self-reported disease, anthropometric (weight, height, waist, and hip circumferences), and biochemical (lipid profile, glycemic, and serum retinol) data were collected. Intestinal permeability was assessed using the lactulose: mannitol (L: M) test, and stratified into percentile ≤ 50 or > 50. Diabetes, hypertension, and overweight were present in 25.9%, 53.7%, and 51.9% of the population, with no significant differences between those with L: M ≤ P50 or > P50. Median L: M was 0.037 (0.014; 0.060). Those with L: M > P50 had significantly lower levels of hip circumference [96.50 (93; 104) cm; P = 0.041] and serum retinol [0.95 (0.60; 1.16) mmol/L; P < 0.001], and these variables were also inversely associated with an odds for a L: M > P50 (AOR 0.93, 95% CI 0.86-0.99; P = 0.042; AOR 0.15, 95% CI 0.05-0.42; P < 0.001, respectively). We concluded that hip circumference and serum retinol were negatively associated with intestinal permeability in the studied elderly, and data indicate that lactulose and mannitol were positively associated with anthropometric and biochemical markers related to metabolic complications.
衰老会降低身体机能，减少瘦体重并削弱免疫功能，这可能会影响肠道形态功能屏障。本研究旨在描述老年人群的肠道通透性及其与心血管疾病风险相关的人体测量学和生化变量之间的关联。对2019年10月至2023年3月期间的54名老年人进行了一项横断面研究。收集了自我报告的疾病、人体测量学数据（体重、身高、腰围和臀围）以及生化数据（血脂谱、血糖和血清视黄醇）。使用乳果糖：甘露醇（L:M）试验评估肠道通透性，并将其分层为百分位数≤50或>50。该人群中糖尿病、高血压和超重的患病率分别为25.9%、53.7%和51.9%，L:M≤P50或>L:M>P50的人群之间无显著差异。L:M的中位数为0.037（0.014；0.060）。L:M>P50的人群臀围[96.50（93；104）cm；P=0.041]和血清视黄醇[0.95（0.60；1.16）mmol/L；P<0.001]水平显著较低，并且这些变量也与L:M>P50的几率呈负相关（调整后的比值比分别为0.93，95%置信区间0.86-0.99；P=0.042；调整后的比值比为0.15，95%置信区间0.05-0.42；P<0.001）。我们得出结论，在所研究的老年人中，臀围和血清视黄醇与肠道通透性呈负相关，数据表明乳果糖和甘露醇与代谢并发症相关的人体测量学和生化标志物呈正相关。
