Jamali Tahereh, Ardestani Sussan Kaboudanian, Vaez-Mahdavi Mohammad-Reza, Rezaei Arezou, Naghizadeh Mohammad Mehdi, Tuserkani Fatemeh, Khazaei HosseinAli, Khodadadi Ali, Khazaei Bahman, Latifi Keivan, Ghazanfari Tooba
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Sci Rep. 2025 Jul 1;15(1):21348. doi: 10.1038/s41598-025-05919-9.
COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay. We conducted DHEAS analysis across different days. COVID-19 patients, particularly inpatients, have lower DHEAS levels compared to controls. DHEAS levels in COVID-19 patients showed a dynamic pattern, with an initial decline followed by recovery. The scatter plot analysis suggested COVID-19 could increase the age-related decline in DHEAS among males. Comorbidities, including hypertension, heart disease, and diabetes mellitus, were prevalent among COVID-19 patients and correlated with disease severity. Hypertension moderated the relationship between hospitalization and DHEAS, especially in females. Our findings showed a significant association between lower DHEAS and COVID-19 severity, along with temporal dynamics. COVID-19's potential to increase the age-related decline in DHEAS, especially in males, underscores its intricate relationship with age. Hypertension's influence on DHEAS suggests a gender-specific effect, emphasizing tailored management approaches. These findings offer valuable insights into the interaction between COVID-19, hormonal dynamics, and demographic factors, suggesting that DHEAS levels may play a role in the pathophysiology of the disease and could be considered alongside other markers.
新冠疫情已在全球范围内影响了数百万人。本研究调查硫酸脱氢表雄酮（DHEAS）作为新冠病毒疾病进展的一个因素，分析其与疾病状态、时间模式、年龄、性别及合并症的关系，以改善治疗结果。采用竞争性化学发光免疫分析法对DHEAS进行定量。我们在不同日期进行了DHEAS分析。与对照组相比，新冠患者，尤其是住院患者的DHEAS水平较低。新冠患者的DHEAS水平呈现动态变化，最初下降随后恢复。散点图分析表明，新冠病毒可能会加剧男性中与年龄相关的DHEAS水平下降。包括高血压、心脏病和糖尿病在内的合并症在新冠患者中很常见，且与疾病严重程度相关。高血压缓和了住院与DHEAS之间的关系，尤其是在女性中。我们的研究结果表明，较低的DHEAS水平与新冠病毒疾病严重程度之间存在显著关联，同时存在时间动态变化。新冠病毒加剧与年龄相关的DHEAS水平下降的可能性，尤其是在男性中，突显了其与年龄的复杂关系。高血压对DHEAS的影响表明存在性别特异性效应，强调了针对性的管理方法。这些发现为新冠病毒、激素动态变化和人口统计学因素之间的相互作用提供了有价值的见解，表明DHEAS水平可能在该疾病的病理生理学中发挥作用，可与其他标志物一并考虑。
