• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

COVID-19 患者脱氢表雄酮（DHEAS）、皮质醇和 DHEAS/皮质醇比值的评估：一项初步研究。

Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study.

机构信息

Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.

Department of Medicine, All India Institute of Medical Sciences, Jodhpur, India.

出版信息

Hormones (Athens). 2022 Sep;21(3):515-518. doi: 10.1007/s42000-022-00382-x. Epub 2022 Jul 8.

DOI:10.1007/s42000-022-00382-x
PMID:35804262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9266078/
Abstract

PURPOSE

Dehydroepiandrosterone sulfate (DHEAS) is observed to be decreased in sepsis and inflammatory conditions. In the present study, we assessed the levels of DHEAS and cortisol and the DHEAS/cortisol ratio and their association with inflammatory markers in patients with COVID-19.

METHODS

The study recruited 76 RT-PCR-positive COVID-19-positive patients and 79 healthy controls. The blood samples were collected and were analyzed for cortisol and DHEAS.

RESULTS

We observed decreased levels of DHEAS and DHEAS/cortisol ratio and increased levels of cortisol in cases when compared with controls. DHEAS and DHEAS/cortisol ratio showed a decreasing trend with the increase in disease severity.

CONCLUSION

The present study is the first of its kind comparing DHEAS levels and DHEAS/cortisol ratio in COVID-19 patients and control subjects. DHEAS, with its inhibitory effect on IL6 and activation of Tregs, may play a crucial role in immune defense mechanisms against COVID-19.

摘要

目的

脱氢表雄酮硫酸酯（DHEAS）在脓毒症和炎症状态下观察到减少。在本研究中，我们评估了 COVID-19 患者中 DHEAS 和皮质醇的水平以及 DHEAS/皮质醇比值及其与炎症标志物的相关性。

方法

该研究招募了 76 名 RT-PCR 阳性 COVID-19 阳性患者和 79 名健康对照者。采集血样并分析皮质醇和 DHEAS。

结果

与对照组相比，我们观察到病例中 DHEAS 和 DHEAS/皮质醇比值水平降低，皮质醇水平升高。DHEAS 和 DHEAS/皮质醇比值随着疾病严重程度的增加呈下降趋势。

结论

本研究是首例比较 COVID-19 患者和对照者 DHEAS 水平和 DHEAS/皮质醇比值的研究。DHEAS 通过抑制 IL6 和激活 Tregs，可能在针对 COVID-19 的免疫防御机制中发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53a/9266078/04dcd05c1dcd/42000_2022_382_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53a/9266078/04dcd05c1dcd/42000_2022_382_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53a/9266078/04dcd05c1dcd/42000_2022_382_Fig1_HTML.jpg

相似文献

1
Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study.COVID-19 患者脱氢表雄酮（DHEAS）、皮质醇和 DHEAS/皮质醇比值的评估：一项初步研究。
Hormones (Athens). 2022 Sep;21(3):515-518. doi: 10.1007/s42000-022-00382-x. Epub 2022 Jul 8.
2
Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.皮质醇/脱氢表雄酮比值与海马体积：一项针对重度抑郁症患者和健康对照者的初步研究。
Psychoneuroendocrinology. 2016 Oct;72:139-46. doi: 10.1016/j.psyneuen.2016.06.017. Epub 2016 Jun 28.
3
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.脓毒性休克中血清脱氢表雄酮与硫酸脱氢表雄酮的解离
J Clin Endocrinol Metab. 2006 Jul;91(7):2548-54. doi: 10.1210/jc.2005-2258. Epub 2006 Apr 11.
4
Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age.人脑脊液中的皮质醇、脱氢表雄酮（DHEA）和硫酸脱氢表雄酮：与血液水平的关系及年龄的影响。
J Clin Endocrinol Metab. 1996 Nov;81(11):3951-60. doi: 10.1210/jcem.81.11.8923843.
5
Association of adrenal function and disease severity in community-acquired pneumonia.社区获得性肺炎中肾上腺功能与疾病严重程度的关联
PLoS One. 2014 Jun 9;9(6):e99518. doi: 10.1371/journal.pone.0099518. eCollection 2014.
6
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach.脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEAS）与情绪加工——一种行为学和电生理学方法
Horm Behav. 2015 Jul;73:94-103. doi: 10.1016/j.yhbeh.2015.06.005. Epub 2015 Jun 27.
7
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?肝硬化合并感染性休克患者的硫酸脱氢表雄酮和硫酸脱氢表雄酮/皮质醇比值：肝肾上腺综合征的又一征象？
Crit Care. 2017 Aug 15;21(1):214. doi: 10.1186/s13054-017-1768-0.
8
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.在健康受试者的促肾上腺皮质激素释放激素试验期间，给予β-肾上腺素能拮抗剂可诱导皮质醇和硫酸脱氢表雄酮的分泌，并抑制促肾上腺皮质激素的分泌。
Eur J Endocrinol. 2003 Jan;148(1):45-53. doi: 10.1530/eje.0.1480045.
9
Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease.慢性炎症性肠病患者炎症的体液标志物与硫酸脱氢表雄酮或皮质醇血清水平的关联
Am J Gastroenterol. 1998 Nov;93(11):2197-202. doi: 10.1111/j.1572-0241.1998.00535.x.
10
Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study.衰老对肾上腺激素水平影响中的性别差异：兰乔贝纳多研究
J Clin Endocrinol Metab. 2000 Oct;85(10):3561-8. doi: 10.1210/jcem.85.10.6861.

引用本文的文献

1
A Pilot Study of the Role of Salivary Biomarkers in the Diagnosis of PCOS in Adolescents Across Different Body Weight Categories.唾液生物标志物在不同体重类别的青少年多囊卵巢综合征诊断中作用的初步研究。
J Clin Med. 2025 Aug 31;14(17):6159. doi: 10.3390/jcm14176159.
2
Correlation between SARS-CoV-2-specific antibody titers and the hormones DHEA, cortisol, testosterone, and progesterone.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）特异性抗体滴度与脱氢表雄酮、皮质醇、睾酮和孕酮激素之间的相关性。
Front Immunol. 2025 Jul 31;16:1560623. doi: 10.3389/fimmu.2025.1560623. eCollection 2025.
3
Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies.

本文引用的文献

1
Blood cortisol and dehydroepiandrosterone sulphate (DHEAS) levels and CD4 T cell counts in HIV infection.
Clin Exp Rheumatol. 1997 Jan-Feb;15(1):87-90.
硫酸脱氢表雄酮（DHEAS）水平与新型冠状病毒肺炎（COVID-19）严重程度、性别、年龄、合并症及治疗策略的关联
Sci Rep. 2025 Jul 1;15(1):21348. doi: 10.1038/s41598-025-05919-9.
4
Sources and control of impurity during one-pot enzymatic production of dehydroepiandrosterone.一锅法酶法生产脱氢表雄酮过程中杂质的来源和控制。
Appl Microbiol Biotechnol. 2024 Jun 29;108(1):399. doi: 10.1007/s00253-024-13221-3.
5
Endogenous serum glucocorticoid concentrations, steroidogenic enzyme activity, and 90-day mortality in patients hospitalized with COVID-19: an observational cohort study.新冠病毒肺炎住院患者内源性血清糖皮质激素浓度、类固醇生成酶活性与90天死亡率：一项观察性队列研究
Endocr Connect. 2024 Jul 13;13(8). doi: 10.1530/EC-24-0093. Print 2024 Aug 1.
6
IL-6 and Neutrophil/Lymphocyte Ratio as Markers of ICU Admittance in SARS-CoV-2 Patients with Diabetes.白细胞介素 6 和中性粒细胞/淋巴细胞比值可作为合并 2 型糖尿病的 SARS-CoV-2 患者入住 ICU 的标志物。
Int J Mol Sci. 2023 Oct 5;24(19):14908. doi: 10.3390/ijms241914908.
7
Meta-Analysis of COVID-19 Metabolomics Identifies Variations in Robustness of Biomarkers.基于 COVID-19 代谢组学的荟萃分析确定了生物标志物稳健性的变化。
Int J Mol Sci. 2023 Sep 21;24(18):14371. doi: 10.3390/ijms241814371.
8
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study.代谢组学导向的纳米技术在病毒性疾病管理中的应用：以COVID-19为例
Pharmacol Rep. 2023 Oct;75(5):1045-1065. doi: 10.1007/s43440-023-00517-w. Epub 2023 Aug 16.
9
Changes in Cortisol Secretion and Corticosteroid Receptors in COVID-19 and Non COVID-19 Critically Ill Patients with Sepsis/Septic Shock and Scope for Treatment.新冠病毒感染和非新冠病毒感染的脓毒症/脓毒性休克重症患者的皮质醇分泌及糖皮质激素受体变化与治疗前景
Biomedicines. 2023 Jun 23;11(7):1801. doi: 10.3390/biomedicines11071801.
10
COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases.2019冠状病毒病、2型糖尿病、内分泌遗传学以及垂体和肾上腺疾病。
Hormones (Athens). 2023 Mar;22(1):1-2. doi: 10.1007/s42000-023-00436-8.