COVID-19 患者脱氢表雄酮（DHEAS）、皮质醇和 DHEAS/皮质醇比值的评估：一项初步研究。
Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study.
机构信息
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Department of Medicine, All India Institute of Medical Sciences, Jodhpur, India.
出版信息
Hormones (Athens). 2022 Sep;21(3):515-518. doi: 10.1007/s42000-022-00382-x. Epub 2022 Jul 8.
PURPOSE
Dehydroepiandrosterone sulfate (DHEAS) is observed to be decreased in sepsis and inflammatory conditions. In the present study, we assessed the levels of DHEAS and cortisol and the DHEAS/cortisol ratio and their association with inflammatory markers in patients with COVID-19.
METHODS
The study recruited 76 RT-PCR-positive COVID-19-positive patients and 79 healthy controls. The blood samples were collected and were analyzed for cortisol and DHEAS.
RESULTS
We observed decreased levels of DHEAS and DHEAS/cortisol ratio and increased levels of cortisol in cases when compared with controls. DHEAS and DHEAS/cortisol ratio showed a decreasing trend with the increase in disease severity.
CONCLUSION
The present study is the first of its kind comparing DHEAS levels and DHEAS/cortisol ratio in COVID-19 patients and control subjects. DHEAS, with its inhibitory effect on IL6 and activation of Tregs, may play a crucial role in immune defense mechanisms against COVID-19.
目的
脱氢表雄酮硫酸酯（DHEAS）在脓毒症和炎症状态下观察到减少。在本研究中，我们评估了 COVID-19 患者中 DHEAS 和皮质醇的水平以及 DHEAS/皮质醇比值及其与炎症标志物的相关性。
方法
该研究招募了 76 名 RT-PCR 阳性 COVID-19 阳性患者和 79 名健康对照者。采集血样并分析皮质醇和 DHEAS。
结果
与对照组相比，我们观察到病例中 DHEAS 和 DHEAS/皮质醇比值水平降低，皮质醇水平升高。DHEAS 和 DHEAS/皮质醇比值随着疾病严重程度的增加呈下降趋势。
结论
本研究是首例比较 COVID-19 患者和对照者 DHEAS 水平和 DHEAS/皮质醇比值的研究。DHEAS 通过抑制 IL6 和激活 Tregs，可能在针对 COVID-19 的免疫防御机制中发挥关键作用。
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