Zhang Dapeng, Mei Jie, He Qiang
Nanjing University of Chinese Medicine Affiliated Nanjing Hospital of Traditional Chinese Medicine, Nanjing, China.
The First Clinical College of Shandong University of Traditional Chinese Medicine, No.4655, University Road, Changqing University Science Park, Jinan, Shandong, China.
Sci Rep. 2025 Jul 1;15(1):21301. doi: 10.1038/s41598-025-06249-6.
This study aims to investigate the association between lipid accumulation product (LAP) levels and osteoarthritis (OA) in participants with normal BMI, and the potential role of the systemic inflammation response index (SIRI) in this association. Participants with normal BMI from the national health and nutrition examination survey (NHANES) database (2009-2018) were included. A weighted multivariable logistic regression was used to analyze the association between LAP levels and OA, and mediation analysis was applied to explore the role of SIRI in this relationship. Among 2408 participants with normal BMI, the average age was 43.85 ± 17.68 years, with 1240 (55%) women, and 210 (8.72%) participants recorded as having OA. Compared with the first quartile, the highest quartile of LAP levels was significantly associated with higher OA prevalence and higher SIRI levels [OA (AOR = 1.969, 95% CI 1.035-3.745, P = 0.039); SIRI (AOR = 1.174, 95% CI 1.029-1.489, P = 0.029)], especially in young women. Compared with the first quartile, the highest quartile of SIRI levels was significantly associated with higher OA prevalence [AOR = 1.542, 95% CI 1.010-2.356, P = 0.045], particularly in young women. The highest quartile of LAP levels was significantly associated with higher OA prevalence, with a portion of the association mediated by SIRI (10.30%), with mediation proportions of 8.92% in younger individuals and 8.69% in women. Even with normal BMI, high LAP levels are significantly associated with a higher prevalence of OA, with part of the association mediated by systemic inflammation, especially in young women.
本研究旨在调查体重指数（BMI）正常的参与者中脂质蓄积产物（LAP）水平与骨关节炎（OA）之间的关联，以及全身炎症反应指数（SIRI）在这种关联中的潜在作用。纳入了来自国家健康与营养检查调查（NHANES）数据库（2009 - 2018年）中BMI正常的参与者。采用加权多变量逻辑回归分析LAP水平与OA之间的关联，并应用中介分析来探讨SIRI在这种关系中的作用。在2408名BMI正常的参与者中，平均年龄为43.85±17.68岁，其中1240名（55%）为女性，210名（8.72%）参与者被记录为患有OA。与第一四分位数相比，LAP水平的最高四分位数与更高的OA患病率和更高的SIRI水平显著相关[OA（比值比[AOR]=1.969，95%置信区间[CI]1.035 - 3.745，P = 0.039）；SIRI（AOR = 1.174，95% CI 1.029 - 1.489，P = 0.029）]，尤其是在年轻女性中。与第一四分位数相比，SIRI水平的最高四分位数与更高的OA患病率显著相关[AOR = 1.542，95% CI 1.010 - 2.356，P = 0.045]，特别是在年轻女性中。LAP水平的最高四分位数与更高的OA患病率显著相关，其中一部分关联由SIRI介导（10.30%），在较年轻个体中的中介比例为8.92%，在女性中的中介比例为8.69%。即使BMI正常，高LAP水平也与更高的OA患病率显著相关，部分关联由全身炎症介导，尤其是在年轻女性中。
