Nikniaz Zeinab, Mahdavi Reza, Bakhtiari Zahra, Maddahi Saeedeh, Masnadi Shirazi Kourosh
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Sci Rep. 2025 Jul 1;15(1):21810. doi: 10.1038/s41598-025-07183-3.
Considering the importance of induction and maintenance of remission in patients with ulcerative colitis (UC), different studies investigated the association between adherence to healthy dietary patterns and disease severity. This cross-sectional study investigated the association between Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet score and disease severity in patients with UC. In this study, 158 patients with UC were included. Disease severity was determined by a gastroenterologist using the Mayo score. We assess the dietary intake over the past year by a 168-item food frequency questionnaire. The MIND diet score was calculated based on the Morris et al. method. The logistic regression was used to analyze the association between disease severity and MIND diet score tertiles, adjusted for demographic, disease-related, and nutritional covariates. The mean age of participants was 42.52 ± 12.61 years old. There were no significant differences in demographic characteristics of patients across different tertiles of the MIND diet score except for prednisolone use, and following a special diet (p < 0.05). The patients in the higher tertiles of the MIND diet score consumed significantly more green leafy vegetables (P < 0.001), other vegetables (P < 0.001), berries (P = 0.02), nuts (P = 0.02), and olive oils (P = 0.0), but consumed less fast fries' foods (P = 0.03) than those in the lower tertiles. The results of adjusted regression showed that compared with the patients in the first tertile of the MIND diet score, the patients in the third tertile had significantly lower odds of disease severity (OR: 0.39, 95% CI: 0.16, 0.97). High adherence to the MIND diet score was significantly associated with lower odds of severe UC. However, more prospective and interventional studies are needed to provide a more complete overview of the association between MIND diet score and UC severity.
考虑到诱导和维持溃疡性结肠炎（UC）患者缓解的重要性，不同研究调查了坚持健康饮食模式与疾病严重程度之间的关联。这项横断面研究调查了地中海-DASH（防治神经退行性延迟）干预饮食（MIND饮食）评分与UC患者疾病严重程度之间的关联。在本研究中，纳入了158例UC患者。疾病严重程度由胃肠病学家使用梅奥评分确定。我们通过一份包含168个项目的食物频率问卷评估过去一年的饮食摄入量。MIND饮食评分基于莫里斯等人的方法计算得出。采用逻辑回归分析疾病严重程度与MIND饮食评分三分位数之间的关联，并对人口统计学、疾病相关和营养协变量进行了调整。参与者的平均年龄为42.52±12.61岁。除泼尼松龙使用情况和遵循特殊饮食外，不同MIND饮食评分三分位数患者的人口统计学特征无显著差异（p<0.05）。MIND饮食评分较高三分位数的患者比低三分位数的患者摄入显著更多的绿叶蔬菜（P<0.001）、其他蔬菜（P<0.001）、浆果（P=0.02）、坚果（P=0.02）和橄榄油（P=0.0），但快餐食品摄入量较少（P=0.03）。调整后的回归结果显示，与MIND饮食评分第一三分位数的患者相比，第三三分位数的患者疾病严重程度的几率显著更低（OR：0.39，95%CI：0.16，0.97）。高度坚持MIND饮食评分与严重UC的几率较低显著相关。然而，需要更多的前瞻性和干预性研究来更全面地概述MIND饮食评分与UC严重程度之间的关联。
