Mo Chaodeng, Bajgai Johny, Rahman Md Habibur, Choe Soonchul, Abdul-Nasir Sofian, Ma Hui, He Wenjing, Pham Thu Thao, Zhang Haiyang, Hoon Goh Seong, Bomi Kim, Kim Cheol-Su, Lee Kyu-Jae, Shin Insik
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju, 26426, Gangwon-do, Republic of Korea.
Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju, 26426, Gangwon-do, Republic of Korea.
Sci Rep. 2025 Jul 2;15(1):22557. doi: 10.1038/s41598-025-09203-8.
Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four 5-min standardized UV exposures (UVB: 1.34 mW/cm²; UVA: 27.7 mW/cm²) on representative skin areas. Blood samples were collected before exposure and after every two sessions to assess serum vitamin D, inflammatory markers, vitamin D-related markers, and oxidative stress indicators. Serum vitamin D concentration significantly increased after four exposures (p < 0.001), while calcium, phosphorus, and parathyroid hormone (PTH) significantly decreased (p < 0.05). Reactive oxygen species (ROS) significantly increased (p < 0.001), but no significant changes were observed in nitric oxide (NO) or myeloperoxidase (MPO) levels. Similarly, inflammatory markers such as C-reactive protein (CRP), MPO, and antioxidant enzymes (glutathione peroxidase [GPx] and catalase [CAT], showed no significant alterations. Among the inflammatory cytokines assessed, interleukin (IL)-1β levels showed a slight increase without reaching significance, and the levels of other cytokines such as IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) showed no marked alterations. In addition, post-exposure skin assessment revealed no adverse effects. Our findings demonstrate that UVR exposure can enhance vitamin D synthesis in healthy adults without significant inflammatory responses or adverse effects, providing a basis for optimizing UV-based interventions to improve vitamin D status through risk management.
紫外线辐射（UVR）对于维生素D的合成至关重要，并影响各种生物过程。本研究调查了可控紫外线暴露对健康成年人维生素D合成和皮肤炎症的影响。在一项随机临床试验中，24名志愿者在具有代表性的皮肤区域接受了四次每次5分钟的标准化紫外线照射（UVB：1.34 mW/cm²；UVA：27.7 mW/cm²）。在照射前以及每两次照射后采集血样，以评估血清维生素D、炎症标志物、维生素D相关标志物和氧化应激指标。四次照射后血清维生素D浓度显著升高（p < 0.001），而钙、磷和甲状旁腺激素（PTH）显著降低（p < 0.05）。活性氧（ROS）显著增加（p < 0.001），但一氧化氮（NO）或髓过氧化物酶（MPO）水平未观察到显著变化。同样，炎症标志物如C反应蛋白（CRP）、MPO以及抗氧化酶（谷胱甘肽过氧化物酶[GPx]和过氧化氢酶[CAT]）也未显示出显著改变。在所评估的炎症细胞因子中，白细胞介素（IL）-1β水平略有升高但未达到显著水平，而其他细胞因子如IL-6、IL-10、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）的水平未显示出明显改变。此外，照射后皮肤评估未发现不良反应。我们的研究结果表明，紫外线暴露可增强健康成年人的维生素D合成，而无明显炎症反应或不良反应，为通过风险管理优化基于紫外线的干预措施以改善维生素D状态提供了依据。
