Gu Hanjiang, Zhang Yufei, Zeng Weihui, Xia Yumin
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Cytokine Growth Factor Rev. 2022 Apr;64:12-20. doi: 10.1016/j.cytogfr.2021.12.002. Epub 2021 Dec 13.
Interferons are multifunctional cytokines not expressed in the skin under normal physiological conditions. However, they are overexpressed in serum and skin lesions of patients with psoriasis and play an important role in the pathogenesis of the disease. Interferons act directly on skin resident cells and recruit and modulate inflammatory cells, thereby exacerbating psoriatic inflammation. They upregulate the expression of relevant cytokines and chemokines, facilitate excessive proliferation of keratinocytes, and enhance the formation of poorly differentiated dermal microvessels. In this review, we summarized the pathogenic effect of interferons on psoriasis and also discussed the therapeutic strategies targeting interferons.
干扰素是多功能细胞因子，在正常生理条件下不在皮肤中表达。然而，它们在银屑病患者的血清和皮肤病变中过度表达，并在该疾病的发病机制中起重要作用。干扰素直接作用于皮肤驻留细胞，募集并调节炎症细胞，从而加剧银屑病炎症。它们上调相关细胞因子和趋化因子的表达，促进角质形成细胞过度增殖，并增强低分化真皮微血管的形成。在本综述中，我们总结了干扰素对银屑病的致病作用，并讨论了针对干扰素的治疗策略。
