Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, 431001, India.
Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2877-2933. doi: 10.1007/s00210-023-02819-5. Epub 2023 Nov 23.
Vitamin D, a fat-soluble vitamin known for its critical function in calcium homeostasis and bone health, is gaining interest for its anticancer properties. Observational studies have suggested a negative relationship between vitamin D levels and the incidence of some malignancies throughout the years, prompting substantial investigation to find its anticancer effects. The purpose of this comprehensive review is to investigate the diverse function of vitamin D in cancer prevention and therapy. We explored the molecular mechanism underlying its effects on cancer cells, which range from cell cycle control and death to angiogenesis and immune response modulation. Insights from in vitro and in vivo studies provide valuable evidence supporting its anticancer potential. Furthermore, we look at epidemiological and clinical studies that investigate the relationship between vitamin D levels and cancer risk or treatment results. Vitamin D supplementation's safety profile and cost-effectiveness increase its attractiveness as an adjuvant therapy in conjunction with traditional treatment regimens. Our critical review of the current literature provides an in-depth understanding of vitamin D's anticancer effect, covering the obstacles and possibilities in realizing its promise for cancer prevention and therapy. The findings of this study might pave the way for the development of innovative treatment techniques that take use of the advantages of vitamin D to fight cancer and improve patient care. As research progresses, a better understanding of vitamin D's anticancer processes will surely simplify its incorporation into personalized cancer care techniques, hence enhancing patient outcomes in the battle against cancer.
维生素 D 是一种脂溶性维生素，以其在钙平衡和骨骼健康方面的关键作用而闻名，近年来，其抗癌特性引起了人们的关注。观察性研究表明，维生素 D 水平与某些恶性肿瘤的发病率之间存在负相关关系，这促使人们进行了大量研究以寻找其抗癌作用。本综述的目的是探讨维生素 D 在癌症预防和治疗中的多种功能。我们探讨了其对癌细胞的作用的分子机制，这些作用范围从细胞周期控制和死亡到血管生成和免疫反应调节。体外和体内研究的见解提供了支持其抗癌潜力的有价值证据。此外，我们还研究了调查维生素 D 水平与癌症风险或治疗结果之间关系的流行病学和临床研究。维生素 D 补充剂的安全性和成本效益增加了其作为与传统治疗方案联合的辅助治疗的吸引力。我们对当前文献的批判性回顾提供了对维生素 D 抗癌作用的深入了解，涵盖了在实现其预防和治疗癌症的承诺方面存在的障碍和可能性。本研究的结果可能为开发利用维生素 D 优势对抗癌症和改善患者护理的创新治疗技术铺平道路。随着研究的进展，对维生素 D 抗癌过程的理解肯定会使其更容易融入个性化癌症护理技术中，从而提高患者在抗癌斗争中的预后。
