Dong Lining, Zhou Wenyu, An Ran, Wang Zheng, Wei Wei, Wei Hongjiang, Wang Zhenchang, Wei Xuan
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No.95, Yong An Road, Xicheng District, Beijing, 100050, China.
College of Engineering Science and Technology, Shanghai Ocean University, No. 999, Huchenghuan Road, Nanhui New City, Shanghai, 201306, China.
NPJ Parkinsons Dis. 2025 Jul 1;11(1):192. doi: 10.1038/s41531-025-01043-7.
The specific mechanism underlying the effect of changes in brain iron content on the development of RBD secondary to PD remains unclear. 27 PD patients with secondary RBD (PD-RBD), 24 PD patients without RBD (PD-RBD), and 32 healthy controls (HCs) were included. Paramagnetic susceptibility was isolated using APART-QSM. The QSM and paramagnetic susceptibility (χ) values of the whole brain and subcortical nuclei were compared among groups. The diagnostic performance was evaluated using receiver operating characteristic curve analysis. Compared with PD-RBD, PD-RBD patients presented a lower χ value in the left middle temporal gyrus. The QSM and χ values of bilateral substantia nigra pars compacta (SNpc) were increased in both groups. The diagnostic performance of the combined index of χ values was superior to that of the QSM value or the single index. In conclusion, paramagnetic susceptibility isolated from QSM is helpful for iron quantification and exploring the mechanism of PD-RBD.
脑铁含量变化对帕金森病继发快速眼动睡眠行为障碍（RBD）发展影响的具体机制尚不清楚。纳入了27例继发RBD的帕金森病（PD-RBD）患者、24例无RBD的帕金森病（PD-RBD）患者和32名健康对照者（HCs）。使用APART-QSM分离出顺磁敏感性。比较了各组全脑和皮层下核团的QSM和顺磁敏感性（χ）值。使用受试者工作特征曲线分析评估诊断性能。与PD-RBD相比，PD-RBD患者左侧颞中回的χ值较低。两组双侧黑质致密部（SNpc）的QSM和χ值均升高。χ值联合指标的诊断性能优于QSM值或单一指标。总之，从QSM中分离出的顺磁敏感性有助于铁定量分析和探索PD-RBD的机制。
