Sannino Anna, Allocca Mariateresa, Scarfì Maria Rosaria, Romeo Stefania, Peluso Valentina, Panariello Gaetano, Schettino Fulvio, Chirico Gaetano, Zeni Olga
Institute for Electromagnetic Sensing of the Environment (IREA), National Research Council of Italy (CNR), Naples, Italy.
Department of Electrical and Information Engineering "Maurizio Scarano" (DIEI), University of Cassino and Southern Lazio, Cassino, Italy.
Sci Rep. 2025 Jul 1;15(1):20614. doi: 10.1038/s41598-025-04834-3.
The fifth generation (5G) network is currently being worldwide spread out, raising questions about its potential health impact. The current study aimed to investigate the effects of a 26.5 GHz 5G electromagnetic field on key cellular endpoints of human neuroblastoma cells. A reverberation chamber-based exposure system was designed and realized which allowed the exposure/sham exposure of cell cultures under highly controlled exposure conditions of both electromagnetic and biological parameters. The suitability of the reverberation chambers to host cell cultures was verified by evaluating cell proliferation and cell cycle progression. The effect of 3 h exposure at specific absorption rate of 1.25 W/kg under both continuous wave and 5G modulated signal was evaluated in terms of cell cycle and DNA damage. In the latter case, the exposure was also given in combination with menadione to account for possible cooperative effects. Results showed absence of effects of exposure given alone and in combination with menadione, when both continuous wave and modulated signals were applied at the mentioned exposure level. Further investigations are needed by varying the exposure and biological parameters to strengthen the absence of effects due to 5G signals in the range of millimeter waves.
第五代（5G）网络目前正在全球范围内铺开，这引发了人们对其潜在健康影响的质疑。当前的研究旨在调查26.5吉赫兹5G电磁场对人神经母细胞瘤细胞关键细胞终点的影响。设计并实现了一种基于混响室的暴露系统，该系统能够在电磁和生物学参数高度可控的暴露条件下对细胞培养物进行暴露/假暴露。通过评估细胞增殖和细胞周期进程，验证了混响室容纳细胞培养物的适用性。在连续波和5G调制信号下，以1.25瓦/千克的比吸收率进行3小时暴露，从细胞周期和DNA损伤方面评估其效果。在后一种情况下，暴露还与甲萘醌联合进行，以考虑可能的协同效应。结果表明，当在上述暴露水平施加连续波和调制信号时，单独暴露以及与甲萘醌联合暴露均未产生影响。需要通过改变暴露和生物学参数进行进一步研究，以强化毫米波范围内5G信号不存在影响这一结论。
